OPEN-LABEL OBSERVATIONAL STUDY TO DETERMINE THE SUCCESS RATE OF FIRST CYCLE INTRA UTERINE INSEMINATION (IUI) INVOLVING LUTEAL PHASE SUPPORT WITH ORAL NATURAL OR SYNTHETIC PROGESTERONE
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2014, Vol 3, Issue 4
Abstract
IUI has been associated with a pregnancy rate of 10–20% per patient, with wide variation, especially in patients undergoing super ovulation for unexplained infertility, female age and amount of motile sperm while receiving adequate luteal phase support. The current study was planned as an epidemiological survey to determine the success rate of IUI when supported with oral natural or synthetic progesterone. Consecutive sixty IUI cycles in women with unexplained infertility were evaluated for serum progesterone levels while assessing the pregnancy rates following the insemination procedure. Patients received either oral natural micronized progesterone sustained release or synthetic progestin (Dydrogesterone) formulation once or twice a day respectively for two to four weeks till the next menses. Pregnancy was confirmed by urinary & biochemical investigation. Three (5%) cases had pregnancy at the first IUI cycle. Sr. Progesterone levels were maintained at ≥14 ng/ml for 56 (93.3%) patients during the mid-luteal phase. There were no side effects reported during the luteal phase administration of oral progesterone. The pregnancy rates could be related to strategy for monofollicular development, first cycle assessment and trend for a lower motile fraction noted in the current study.
Authors and Affiliations
Gopinath PM| Consultant, Centre for Assisted Reproduction, Sooriya Hospital, Chennai, Tamil Nadu, India, Corresponding author email: pmgnath@gmail.com, Desai RR| Senior Resident, Department of Pharmacology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India
Keywords
Related Articles
- EP ID EP11320
- DOI 10.5958/2319-5886.2014.00028.9
- Views 277
- Downloads 16
NONLINEAR DYNAMIC ANALYSIS OF VOICE: A NORMATIVE STUDY IN THE INDIAN POPULATION
Background: The aim of this study was to establish normative data for the Indian population using Nonlinear dynamic analysis. In this study, correlation dimension, a measure of nonlinear dynamic analysis was performed f...
THE EFFECT OF DIFFERENT BOUTS OF EXERCISE ON WEIGHT LOSS IN OVERWEIGHT INDIAN FEMALE UNDERGRADUATES
Background: The prevalence of obesity is increasing globally and in India with lack of sufficient time for continuous exercise being one of the causes. Performing multiple short bouts of exercise has been introduced as...
Comparing the satisfaction of patients before and after the implementation of the healthcare reform in hospitals of Qazvin, 2015
Preservation and promotion of health, which is an important asset, should be considered as the most important efforts of everyday life. The main goal of healthcare reform is to create health equity. This study aimed to...
Determination Effective Elements of Continuing Interprofessional Education Models
Background: Traditional continuing education (CE) approaches have limited impact on patient management and outcomes. Continuing interprofessional education is an innovated educational approach that can improve patient...
Mediterranean Diet in Prevention of Chronic Diseases
Bad eating habits lead to the emergence of chronic health problems such as coronary artery diseases, hypertension, dyslipidaemia, cancer and obesity and the relationship between diet and diseases is emphasized and the r...