Open Label, Switch Over, Two Phased, Comparative Efficacy Trial Between Sodium Valproate and Magnesium Valproate in Patients of Bipolar Disorder
Journal Title: PARIPEX-Indian Journal of Research - Year 2016, Vol 5, Issue 2
Abstract
The present study aimed to compare efficacy between sodium valproate and magnesium valproate in patients of bipolar disease. The study was done at department of psychiatry at NSCB Medical Hospital, it was of 1 year and number of patient recruited after detailed examination and considering inclusion and exclusion criteria were 60. It was an open label, switch over, two phased comparative study where each patient first received 1000 mg of sodium valproate for 15 days, after that efficacy assessment was done. In the second phase patient was switched over to magnesium valproate where intially750 mg of magnesium valproate was given and again after 15 days 1250 mg of magnesium valproate was given and efficacy was assessed. Patients were evaluated for efficacy by Youngs Mania Rating Scale (YMRS), BPRS and CGI. Statistical analysis was done by using SPSS18. It was found out that both salts of valproic acid were equally efficacious as both causes significant reduction (p<.0001) in YMRS, CGI and BPRS, though reduction is highest for 1250 mg magnesium valproate followed by1000 mg of sodium valproate and lastly for 750 mg of magnesium valproate.
Authors and Affiliations
Dr Prakash kumar dubey, Dr Himanshu Sharma, Dr Omprakash Raichandani
Keywords
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