Optic nerve compression: the role of the lamina cribrosa and translaminar pressure
Journal Title: International Journal of Ophthalmology - Year 2017, Vol 10, Issue 12
Abstract
"AIM: To describe the morphological changes of the lamina cribrosa (LC) in patients with optic nerve compression. METHODS: Cross-sectional study. Twenty eyes with optic nerve compression, affected by Graves' ophthalmopathy (GO) were compared with 18 refractive error-matched healthy eyes. The following examinations were performed: best-corrected visual acuity (BCVA), intraocular pressure, optic nerve echography, visual field, SD-OCT including the retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and LC thickness and extent. RESULTS: A-scan revealed significant differences in the subarachnoid space (SAS) between the affected and control groups. LC thickness and LC area were 233 µm (SD 23) and 0.41 mm2 (SD 0.19), respectively. Average GCC thickness (P=0.0005), LC thickness (P=0.001), MD (P=0.001) and PSD (P=0.001) differed significantly between the two groups; whereas LC area (P=0.2) and average RFNL (P=0.1) did not. CONCLUSION: Optic nerve compression reduces the SAS thereby altering the morphology of LC thickness and causing GCC damage."
Authors and Affiliations
Gilda Cennamo
Keywords
Related Articles
- EP ID EP592165
- DOI 10.18240/ijo.2017.12.15
- Views 49
- Downloads 0
Evaluation of hyperreflective foci as a prognostic factor of visual outcome in retinal vein occlusion
"AIM: To evaluate the potential role of hyperreflective foci (HF) as a prognostic indicator of visual outcome in patients with macular edema (ME) due to retinal vein occlusion (RVO). METHODS: We retrospectively reviewed...
Abnormalities of interhemispheric functional connectivity in individuals with acute eye pain: a resting-state fMRI study
"AIM: To study the changes of the resting state functional connectivity (rsFC) between acute eye pain (EP) subjects and healthy controls (HCs) in the two hemispheres by using voxel-mirrored homotopic connectivity (VMHC)...
Lamina cribrosa thickness in children with hyperopic anisometropic amblyopia
"AIM: To determine lamina cribrosa thickness (LCT) in the optic nerve head region of the eyes in children with hyperopic anisometropic amblyopia and to compare this thickness with that of fellow eyes, hyperopic non-ambly...
A novel splice site mutation of CRYBA3/A1 gene associated with congenital cataract in a Chinese family
"AIM: To identify the disease-causing mutation responsible for the presence of congenital cataract in a Chinese family. METHODS: The study recruited a four-generation Chinese pedigree affected by autosomal dominant conge...
Scanning-slit topography in patients with keratoconus
"AIM: To evaluate the anterior and posterior corneal surfaces using scanning-slit topography and to determine the diagnostic ability of the measured corneal parameters in keratoconus. METHODS: Orbscan II measurements wer...