Optimal cytoreduction is the only independent prognostic factor for survival in women with ovarian clear cell carcinoma
Journal Title: Medical Science and Discovery - Year 2015, Vol 2, Issue 6
Abstract
Objective: To evaluate the clinicopathological characteristics, treatment methods, survival, and prognosis of ovarian clear-cell carcinoma (OCCC).Material and Methods: All patients with OCCC who were treated between January 1998 and October 2012 were retrospectively reviewed. After the exclusion criteria, a total of 39 women were included in the present study. Univariate and multivariate analyses were used to identify the risk factors for overall survival (OS) and progression-free survival (PFS).Results: The majority of the patients were at stage I disease (n=21 [24.3%]). All patients underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. Additionally only pelvic, and pelvic plus para-aortic lymphadenectomy was done in 8 (20.5%) and 19 (48.8%) women, respectively. Optimal cytoreductive surgery was achieved in 26 (66.7%) patients. Recurrences occurred in 11 (28.2%) patients. The median follow-up period was 51 months (range 4 – 132 months). The 5-year PFS and OS rates were 47% and 54%, for all patients. The 5-year OS rates for women with early (stage I and II) and advanced (stage III and IV) stage disease were 56.4% and 38.1%, respectively. Multivariate analysis confirmed optimal cytoreduction as the only independent predictor of OS [Odds ratio (OR) 21.212, 95% confidence interval (CI) 5.259–85.556, (p<0.001)]Conclusion: Optimal cytoreductive surgery is the only independent good prognostic factor for survival in patients with OCCC.
Authors and Affiliations
Ulas Solmaz, Emre Mat, Atalay Ekin, Levent Dereli, Özgür Turan, Gulsah Demirtas, Cenk Gezer, Pinar Hasdemir, Sevil Sayhan, Muzaffer Sanci
Keywords
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