Optimization and Characterization of Transdermal Ethosomal Gel of Fluoxetine by Hot Method.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 1
Abstract
The current exploration is to develop Transdermal Ethosomal Gel of Fluoxetine using hot method. The study incorporates 32 factorial design for optimization of lecithin and ethanol which are considered as independent variables and drug content, entrapment efficacy, and vesicular size as dependent variables. The in-vitro studies reveal that F8 with lecithin: ethanol ratio 200:3, drug content of 95.658%, and entrapment efficacy of 93.853% is considered as optimized. Further, ANOVA studies and polynomial equations reveal the effect of lecithin on dependent variables and strengthen the statistical data. Hence, we conclude that the prepared Ethosomal Gel meets the specified criteria.
Authors and Affiliations
A. Tejaswini
Keywords
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