OPTIMIZATION AND SOLUBILIZATION STUDY OF NANOEMULSION BUDESONIDE AND CONSTRUCTING PSEUDOTERNARY PHASE DIAGRAM
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 1
Abstract
Objective: The aim of the present study was to formulate and optimize budesonide nanoemulsions for targeting inflammation.Methods: Budesonide is only found in individuals that have used or taken this drug. It is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. The exact mechanism of the action of budesonide in the treatment of Crohn’s disease is not fully understood. However, being a glucocorticosteroid, budesonide has a high local anti-inflammatory effect. The formulation was optimized for different components and the solubility study for the oil in surfactant and cosurfactant mix ratio was optimized using ternary phase diagram.Results: The surfactant mix ratio was optimized as 1:3 where the maximum concentration of the oil has solubilized and the nanoemulsion area was increased.Conclusion: Budesonide nanoemulsion for targeting inflammation and the pseudoternary phase diagram for the solubility studies and the components of different phases were optimized and achieved through this study.
Authors and Affiliations
Raman Kumar Puppala, Vijaya Lakshmi A
Keywords
Related Articles
- EP ID EP607201
- DOI 10.22159/ajpcr.2019.v12i1.28686
- Views 131
- Downloads 0
EVALUATION OF ANTIBIOTICS USED IN PATIENTS WITH ACUTE RESPIRATORY INFECTIONS IN A HOSPITAL
Objective: This study evaluated the use of antibiotics in the treatment of patients with acute respiratory infection (ARI) in the outpatients installation in Bunda Thamrin General Hospital, Medan. Methods: This prospect...
ANALYSIS OF PHYTO-CONSTITUENTS, ANTIOXIDANT, AND ALPHA AMYLASE INHIBITORY ACTIVITIES OF PERSEA AMERICANA MILL., RHODODENDRON ARBORETUM SM. RUBUS ELLIPTICUS SM. FROM ARGHAKHANCHI DISTRICT NEPAL
Objective: To evaluate the phytochemical, antioxidant activities, and α-amylase inhibition assay for methanolic extract of three ethnomedicinal plants, namely Persea americana Mill., Rubus ellipticus Sm., and Rhododendr...
ALZHEIMER’S DISEASE: A CONSEQUENCE OF IMPAIRED MITOPHAGY?
Neurodegenerative disorders involve complexities of the pathologies, characterized by the progressive loss of neuronal viability, leading to severe physical and cognitive impairments in affected patients. These disorders...
DETERMINATION OF BIOACTIVE COMPONENTS OF BARLERIA COURTALLICA NEES (ACANTHACEAE) BY GAS CHROMATOGRAPHY–MASS SPECTROMETRY ANALYSIS
Objective: The present investigation was carried out to determine the possible bioactive components of stem, root, and leaf of Barleria courtallica Nees using a gas chromatography–mass spectrometry (GC-MS).Methods: The...
PHARMACOKINETIC COMPARISON OF MONTELUKAST SODIUM FORMULATIONS AFTER A SINGLE ORAL DOSE IN HEALTHY GUINEA PIGS
Objective: Pharmacokinetic evaluation of montelukast sodium chronomodulated capsules (sustained-release solid dispersion of drug enclosed in pH-sensitive film-coated hard gelatin shell) and marketed tablets has been carr...