Optimization of Synthesis Process of 4-Methylquinazoline
Journal Title: International Research Journal of Pure and Applied Chemistry - Year 2017, Vol 14, Issue 3
Abstract
4-Methylquinazoline was synthesized with 2-aminoacetophenone and formamide as the starting materials. The reaction conditions, including catalyst, ratio of substrates, temperature and time were optimized. Results showed that the optimal condition were as follows: Catalyst BF3-Et2O, the molar ratio of 2-aminoacetophenone: BF3-Et2O = 1:0.5, the weight ratio of 2-aminoacetophenone: formamide = 1:52, temperature 150°C, and time 6 h. Under the optimal conditions, the yield of the reaction achieved the highest (86%), which are better than the past reports.
Authors and Affiliations
Juan Liu, Yun Yang, Liangchun Li
Keywords
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- EP ID EP321289
- DOI 10.9734/IRJPAC/2017/35918
- Views 80
- Downloads 0
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