Oral Candidiasis: Complication of Concomitant Chemo-radiotherapy in Patients with Oral Squamous Cell Carcinoma
Journal Title: Microbiology Research Journal International - Year 2016, Vol 11, Issue 1
Abstract
Objectives: To investigate oral candidiasis clinically and cytologically in patients with oral squamous cell carcinoma cancer before and at the end of concomitant chemo-radiation therapy and to explore its association with clinical oral symptoms and days of Chemo-radiation. Secondary objective was to describe the oral candidiasis incidence in Pakistani patients with oral squamous cell carcinoma undergoing chemo-radiotherapy. Subjects and Methods: 85 patients who received concomitant chemo-radiotherapy (CCRT) for the treatment of oral squamous cell carcinoma (OSCC) first time were included in this study. Patients were examined for signs and symptoms of oral candidiasis, mucositis and xerostomia before and at the end of CCRT. Oral scrapings were obtained from contralateral normal buccal mucosa and peri-tumoural area on the selected days i.e. before and at the end of CCRT. Cytological examination was carried out using H&E stain and GMS stain. Mucositis, oral hygiene and xerostomia were assessed by self-reporting questionnaires and also subjectively. Associations among oral candidiasis and these symptoms were evaluated. Age, gender and addictive habits of patients were recorded in a specially designed proforma. Results: The incidence of oral candidiasis, mucositis and xerostomia were significantly higher at the end of CCRT in these patients. Cytological examination reveals an increase in incidence of fungal colonization at the end of therapy smears on both sites (contralateral normal buccal mucosa and peri tumoural area). Significant association was observed at the end of CCRT between candidiasis and radiotherapy dosage (p = 0.000), oral hygiene and candidiasis (p = 0.012) (p =0.001), addictive habits of patients and candidiasis (p = 0.012), xerostomia and candidiasis (p = 0.000). Similarly significant association was observed among days of CCRT and fungal colonization on both sites of smears i.e. contralateral normal buccal mucosa and peri- tumoural area (p = 0.000). Conclusion: Oral squamous cell carcinoma patients who have received concomitant chmeo-radiotherapy had a high incidence of fungal colonization in the oral cavity. As a result, prophylaxis to decrease candidal infection in these patients is requisite. This might improve the quality of life of patients who have be given chemo- radiation treatment for malignant oral cancers.
Authors and Affiliations
Sadia Minhas, Muhammad Kashif, Wasif Altaf, A. H. Nagi
Keywords
Related Articles
- EP ID EP350731
- DOI 10.9734/BMRJ/2016/21921
- Views 66
- Downloads 0
Analyzing Different Acetyl Co-A Metabolizing Enzymes as Potential Drug Targets against Mycobacterium tuberculosis
Mycobacterium tuberculosis, the causative agent of tuberculosis, is responsible for the deaths of million people around the globe. The scenario is worse than ever due to the emergence of drug resistant strains which are...
Characterization of Plant Growth Promoting Rhizobacteria Isolated from Chickpea (Cicer arietinum)
Aims: To isolate bacterial strains from chickpea rhizospheric soil and nodules, to characterize and identify potential bacterial strains by using 16S rRNA gene sequencing. Place and Duration of Study: Department of Soi...
A Peculiar Phenomenon of Cold-shocked Bacteria Recovered on Sano- Gam Media
This study was conducted in order to display the peculiar appearance of bacteria which were recovered on Sano-Gam Media. The studied bacteria were Escherichia coli, Salmonella spp., Staphylococcus aureus, Proteus vulgari...
Lactic Acid Bacteria Composition of Type II Sourdough Produced in Nigeria
Aim: The aim of the study was to determine the lactic acid bacteria composition of type II sourdough produced in Nigerian from different brands of wheat flour. Study Design: Sourdoughs were produced by spontaneous fermen...
Prevalence and Antbiogram of Bacterial Isolates Causing Urinary Tract Infections at Federal Teaching Hospital Abakaliki I (FETHA I)
Aims: This study is aimed to ascertain the prevalence and antibiogram of bacterial isolates causing urinary tract infection in Federal Teaching Hospital Abakaliki I (FETHA I) with the view to establishing a base line for...