ORAL GLUCOSE TOLERANCE TESTS WITH NON-BOILED AND BOILED MOMORDICA CHARANTIA FRUITS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 11
Abstract
Background: The fruits of Momordica charantia L. are considered to lower blood glucose levels and as such are consumed in the raw state in Bangladesh. The fruits are also consumed in the cooked form as a vegetable. Since cooking involves boiling or steaming, it was of interest to evaluate antihyperglycemic activity of boiled versus nonboiled fruits. Methods: Antihyperglycemic activity was determined through oral glucose tolerance test (OGTT) in mice. Results: Administration of methanol extract of non-boiled Momordica charantia fruits (MEMC-NB) at doses of 100 and 200 mg per kg body weight to glucose-loaded mice reduced blood glucose levels by 17.4 and 26.2%, respectively. Methanol extract of boiled fruits (MEMC-B) at the same two doses reduced blood glucose levels by 23.2 and 30.2%, respectively. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 51.0%. Conclusion: Methanolic extract of fruits of Momordica charantia (MEMC) can be antihyperglycemic in both non-boiled and boiled form. However, boiling induced a higher lowering of blood glucose suggesting that the fruits possibly will be better for diabetic patients when consumed in the cooked form for lowering blood glucose.
Authors and Affiliations
Dr. Mohammed Rahmatullah
Keywords
Related Articles
- EP ID EP619111
- DOI -
- Views 149
- Downloads 0
IRRITABILITY IN SKIN WITH PRODUCTS WITH MENTHOL AND CAMPHOR. BASE TEST
A study was conducted to determine the sensitizing effect of ointments and possible dermal irritability. The study was carried out in albino rabbits by the general method of irritability in skin analysis using the techni...
PHARMACOKINETICS AND TISSUE RESIDUES OF MARBOFLOXACIN IN NORMAL AND EXPERIMENTALLY ESCHERICHIA COLI INFECTED BROILER CHICKEN
The pharmacokinetic parameters of marbofloxacin were studied following intravenous and oral (single & repeated) administrations in normal and experimentally Escherichia coli infected broiler chicken. Following a single i...
EVALUATION OF THE PROTECTIVE ROLE OF MORINGA OLEIFERA LEAF EXTRACT IN MALE MICE TREATED WITH PARACETAMOL USING MOLECULAR ASSAYS.
The leaves of Moringa oleifera have antioxidant compounds such as carotenoids, ascorbic acid, phenolics and flavonoids. The present study was conducted to assess the protective role of Moringa oleifera leaves extract aga...
PRELIMINARY PHYTOCHEMICAL SCREENING OF QUERCUS INFECTORIA GALLS
Introduction: Medicinal plants are a rich source of producing wide number of chemical constituents, the beneficial medicinal effects of the medicinal plant materials typically result from the combinations of secondary pr...
ENHANCED CYTOTOXIC ACTIVITY OF NOVEL SYNTHESIZED SULFADIAZINE DERIVATIVES BOUND LIPOSOMES TOWARDS BREAST CANCER CELL LINE: COMPARATIVE STUDIES WITH DIFFERENT CELL LINES
The present study aims to evaluate the cytotoxic efficacy of sulfadiazine derivative N-(4,6-bis (4-methoxyphenyl) pyrimidin-2-yl) benzenesulfonamide (G16) and its conjugation with L-α-Phosphatidylethanolamine (Cephalin)...