Oral Midazolam as a Pre-Medication in Paediatric Patients
Journal Title: MVP Journal of Medical Sciences - Year 2017, Vol 4, Issue 1
Abstract
Introduction: In some medical circumstances, pediatric patients may need premedication for transferring to the operating room. In these situations, using oral premedication is preferred. We assessed the efficacy and safety of oral midazolam to reduce the anxiety and improve behavior in children undergoing general anesthesia. Method: In a double-blind randomized clinical trial, 90 children aged between 1-8 years were assigned to one of three oral premedication groups by random selection. Each group contained 30 children. Group I received 0.5 mg/kg oral midazolam Group II received 0.75 mg/kg oral midazolam both in 25% dextrose to a total volume of 5 ml. Group III or control group received 5 ml of 25% dextrose. To study its acceptility, onset and level of sedation, changes in vitals like pulse rate, blood pressure and emotional state before and after sedation, and post-op side effects. Disscussion: After premedication, difference in pulse rate, systolic blood pressure and respiratory rate between the three groups was not statistically significant sedation at 30 minutes after premedication was better in study group II as compared to study group I Emotional state was concluded to be better in study Group II (0.75 mg/ kg) as compared to study group I (0.5 mg/kg) at the time of separation from parents. More post operative complications like nausea, vomiting, giddiness, headache with a dose of 0.75 mg/kg than with a dose of 0.5 mg/kg. Conclusion: So we conclude that oral midazolam in a dose of 0.5 mg/kg for premedication in pediatric patients at it provides good to excellent sedation at 30 minutes at the time of separation from parents, with better quality of separation, and stable emotional state at induction without significant hemodynamic changes with less postoperative
Authors and Affiliations
Jayashree Phaltankar, Milin Shah
Keywords
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- EP ID EP430748
- DOI 10.18311/mvpjms/2017/v4i1/12464
- Views 109
- Downloads 0
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