Oral Mucosal Immune Suppression, Tolerance and Silencing: A Mini-Review
Journal Title: Modern Approaches in Dentistry and Oral Health Care - Year 2018, Vol 1, Issue 2
Abstract
The mucosal immune system spans the mucosal surfaces of the oro-pharyngeal cavity, gastrointestinal tract, respiratory tract, as well as the exocrine glands. In this mini-review the pathogenesis, pathophysiology of oral immunity, tolerance and resilence are discussed, with a special emphasis on the the oral microbiome in immune disorders. The oral-pharyngeal cavity is colonized by various microorganisms. In addition to microbes, food particles and external substances consumed through the oral cavity present potential challenges to the homeostasis of the oral mucosa. Hence, a mucosal membrane and inherent mucosal immune system are indispensable for the protection of the integrity of the internal environment. The mucosal immune system mounts immune response through immune cells residing in mucosal compartments. T lymphocytes residing in the mucosa play important roles in mucosal immunity and tolerance. In addition, T cell deficiency or defects in T cell function are associated with several oral mucosal diseases [1]. The mucosal immune system spans the mucosal surfaces of the oralpharyngeal cavity, gastrointestinal tract, respiratory tract, as well as the exocrine gands [1].
Authors and Affiliations
Michael AB Naafs
Keywords
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- EP ID EP600182
- DOI 10.32474/MADOHC.2018.01.000109
- Views 76
- Downloads 0
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