Oral Ulcer Healing after Treatment with Distilled Liquid Smoke of Coconut Shell on Diabetic Rats
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2019, Vol 8, Issue 2
Abstract
Background: Distilled liquid smoke from coconut shell (Cocos nucifera L.) by pyrolysis process with final temperature 4000C and then distilled in 120-1500C. The characteristics of distilled liquid smoke are yellow liquid, with acidity 2.39 and density 1.0643 g/cm3. The major identified compounds arephenol (36.6%), 2-methoxyphenol (guaiacol) (25.2%), furfural (17.8%), 2-methoxy-5-methylphenol (5.2%) and 4-ethyl-2-methoxyphenol (EMP) (3.5%) with 28 other minor constituents by GCMS. Aim and Objectives: Distilled liquid smoke was examined to investigate its potential therapeutic to oral ulcer healing and diabetic condition on the rat. Furthermore, the clinical oral ulcer healing was evaluated based on ulcer size and diabetic was evaluated based on Fasting Blood Glucose (FBG) and body weight changes. Material and Methods: Diabetes was induced by alloxan. Seventy-two hours after injection, the diabetic condition was confirmed with FBG of >200mg/dl, then the labial fornix anterior was injured to induce oral ulcer using round steel blade. Results: The clinical oral ulcer healing was improved after treatment with distillated liquid smoke compared to benzydamine hydrochloride and aquadest sterile for three days (p=0.005) and seven days (p=0.000). Treatment for seven days with distilled liquid smoke showed significant improvement of the body mass changes compared to benzydamine hydrochloride (p=0.008) and aquadest sterile (p=0.002). There was no improvement of FBG after treatment with distilled liquid smoke (p=0.152). Conclusion: Treatment with distilled liquid smoke coconut shell can improved oral ulcer healing and body weight changes, but not FBG changes.
Authors and Affiliations
Meircurius Dwi Condro Surboyo, Diah Savitri Ernawati, Ira Arundina, Retno Pudji Rahayu
Keywords
Related Articles
- EP ID EP567291
- DOI -
- Views 88
- Downloads 0
Ranula – A Case Report
The term ranula is derived from a latin word “rana” which means “frog.” Ranula is a mucous containing swelling that occurs in the floor of the mouth. It usually presents as a well circumscribed, soft, bluish swelling...
Assessment of Risk Factors for Conversion from Difficult Laparoscopic to Open Cholecystectomy - A Hospital Based Prospective Study
Background: Laparoscopic cholecystectomy is the gold standard in the treatment of gallstones. It has proved to be an effective and safe procedure both in elective and emergency conditions; however, conversion to open sur...
Prevalence of Obesity and Overweight in Preschool Children in Northwest of Tehran, Iran
Background: Nowadays childhood overweight and obesity are considered as a global epidemic, the prevalence of childhood obesity is increasing in the Iran. Aim and Objectives: For prevention and control the disease, knowle...
Large Pseudocyst of the Adrenal Gland: A Radiological Pathological Correlation
Cystic lesion of adrenal gland is an uncommon entity and many are found incidentally. Large adrenal cysts can sometimes found to be associated with abdominal discomfort. These entities can also be associated with hemorrh...
Association of Maternal Vitamin C Status with Gestational Diabetes Mellitus
Background: The role of antioxidants in the etiology of gestational diabetes mellitus (GDM) has been given limited attention. Vitamin C is a nutrient with radical quenching property and has been claimed to influence...