Organ-specific autoimmunity in type 1 diabetes mellitus: Screening with respect to glycemic control

Journal Title: International Journal of Medical Research & Health Sciences - Year 2016, Vol 5, Issue 1

Abstract

Type 1 diabetes (T1D) is a tissue-specific autoimmune disease and often associated with other autoimmune diseases; so our study aimed to define the occurrence of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) in autoimmune thyroid disease (AIT), tissue transglutaminase antibody (TTGAb) in celiac disease, And to evaluate the relationship between the presence of these antibodies and glycemic control. Our retrospective study included 60 Kuwaiti patients with T1D who attended and follow in Diabetes outpatient clinics of Kuwait primary health care centers during the period of 2014-2015. For them, recorded data for age, sex, duration of diabetes, Body Mass Index (BMI), HbA1c was reviewed. Patients were screened for the presence of Specific antibodies to islet antigens (ICAb), glutamic acid decarboxylase autoantibodies (GADAb), insulin autoantibodies (IAA), TPOAb, TGAb, TTGAb and also thyroid stimulating hormone (TSH) were measured by ELISA. Of the total 60 patients (20 men, 40women, mean age was17.95 ± (5.44) y; the mean duration of diabetes was 6.63 ± (4.27) y; mean HbA1c was 10.41± (1.96) %. Only 58 (96.7%) were positive for GADAb, 32 (53.3%) were positive for ICAb, and 48 (80%) were positive for IAA, 14 (23.3%) patients were positive for TPOAb, 11 (18.3%) were positive for TGAb, 10 (16.7 %) were positive for both TPOAb and TGAb; furthermore 8 (13.3%) patients were positive for TTGAb. Neither organ-specific autoimmune disease (AIT and celiac disease) nor pancreatic β cells autoantibodies had a significant association with the glycemic control. In our study, we confirmed the high prevalence of a second organ-specific autoimmune disease in individuals with type 1 diabetes. Also Subclinical forms of these disorders have no influence on diabetes control. Further research will be necessary to test these relationships in a prospective follow-up study.

Authors and Affiliations

Elsayed Amira M

Keywords

Related Articles

Scope of patient registries for rare diseases in India

Rare diseases are difficult to treat and research upon and signify a global medical concern. There have been crucial advances in research and funding on rare diseases in several countries. The challenge is immense for In...

Study of serum levels of calcium, phosphorus and alkaline phosphatase in chronic kidney disease

Chronic kidney disease (CKD) is a worldwide public health problem, with increasing prevalence and lethal adverse outcomes like progressive loss of kidney function, cardiovascular disease and premature death. Disturbances...

Dialysis Modality Preferences and Quality of Life of Adolescents with Renal Failure

The present research explored the differences in perceived quality of life of adolescents afflicted with End stage renal disease (ESRD)/ renal failure with reference to different dialysis modality. It was hypothesized th...

Good practices in the conduct of a patient registry

A patient registry is defined as “a structured system that practices observational study methods to collect constant data (clinical and other) to evaluate detailed outcomes for a population defined by a particular diseas...

A seroprevalence evaluation study of Hepatitis B virus, Hepatitis C virus and Herpes Simplex Virus - 2 among a special study group

Viral STI are silent diseases. Most of them are symptomless, but have the potential to be transmitted to fetus and other sexual partners. Female sex workers, men who have sex with men are at high risk of getting STIs an...

Download PDF file
  • EP ID EP248388
  • DOI -
  • Views 98
  • Downloads 0

How To Cite

Elsayed Amira M (2016). Organ-specific autoimmunity in type 1 diabetes mellitus: Screening with respect to glycemic control. International Journal of Medical Research & Health Sciences, 5(1), 140-144. https://europub.co.uk/articles/-A-248388