ORO DISPERSIBLE TABLETS: A REVIEW
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 7
Abstract
The need for delivering drugs to patients efficiently with minimum side effects has prompted pharmaceutical industries to be engaged in development of new drug delivery systems. To troubleshoot such problems a new dosage form known as orally disintegrating tablet (ODT), has been developed which rapidly disintegrate & dissolve in saliva and then easily swallowed without need of water which is a major benefit over conventional dosage form. In addition, patients suffering from dysphasia, motion sickness, repeated emesis and mental disorders prefer such preparation because they cannot swallow large quantity of water. According to European Pharmacopoeia, the ODT should disperse/disintegrate in less than three minutes. ODT can be prepared by many technologies like lyophilization, molding, spray drying, cotton candy and compression etc. These techniques render disintegration of tablet rapidly and dissolving mouth without chewing or additional water intake. But among these technologies direct compression is most convenient and cheap way to produce tablets with sufficient structural integrity. The bioavailability of some drugs may be increased due to absorption of drugs in oral cavity and also due to pregastric absorption of saliva containing dispersed drugs that pass down into the stomach. Moreover, the amount of drug that is subject to first pass metabolism is reduced as compared to standard tablets. The current article is focused on ideal characteristics, advantages and disadvantages, various technologies developed for ODT, evaluation methods along with recent research and future potential.
Authors and Affiliations
Saurabh Thapliyal
Keywords
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