Osteoblast activation factors in HIV-infected patients on antiretroviral therapy
Journal Title: Postępy Nauk Medycznych - Year 2010, Vol 23, Issue 10
Abstract
<b> Objectives.</b>Bone diseases: osteoporosis, osteopenia and aseptic bone necrosis are relatively common in HIV-infected patients on combined antiretroviral therapy (cART). Pathogenesis of this abnormalities on cART are still unclear. We measured changes of biochemical factors of osteoblast activation: parathyroid hormone (PTH) and osteocalcin (BGP) serum concentrations in patients on ART.<br><b> Material and methods.</b> In 36 patients(pts) without clinical symptoms of bone diseases, before and after one or two years of ARV, retrospectively PTH and BGP serum concentrations, using Diagnostic Systems Laboratories ELISA tests, were measured.<br><b> Results. </b> Of 36 patients involved in the analysis (mean age: 40.4 ± 10.5 yrs), 11 (31%) were female and 25 (69%) were male. Elevated serum PTH level in 4 (11%) pts before and 7 (19%) pts past one or two years of ART were detected. Mean serum PTH concentration before ART. (PTH 1): 22.9 ± 28.5 pg/ml and after start of ART (PTH 2): 33.5 ± 34.0 pg/ml were assessed. Osteocalcin mean serum level before ART (BPG 1): 8.4 ± 7.9 ng/ml and past start of ART (BGP 2): 15.4 ± 12.7 ng/ml were measured. Increase of parathyroid hormone and osteocalcin concentrations in treated pts were statistically significant in Wilcoxon matched pairs tests (p<0.05).<br><b> Conclusions.</b> Examination of PTH and osteocalcin serum concentrations during currently used antiretroviral therapy may be helpful in early detection of bone mineralization abnormalities in HIV-infected patients without clinical symptoms of bone diseases. Standard method used for diagnose osteopenia and osteoporosis is the bone mineral density (BMD), measured with dual X-ray absorptiometry (DEXA).
Authors and Affiliations
Dorota Bander, Magdalena Leszczyszyn-Pynka, Miłosz Parczewski, Anna Boroń-Kaczmarska
Keywords
Related Articles
- EP ID EP53762
- DOI -
- Views 160
- Downloads 0
Komentarz
Neuronal channelopathies
Ion channels are specialized proteins of the cell membrane which transports ions across the membrane. Ion channels are widely expressed both in excitable cells (neurons, muscles) and in the other cells (renal tubules, ep...
The use of fine needle aspiration biopsy in the diagnosis of thyroid nodules
Introduction. Fine needle aspiration (FNA) is a simple, inexpensive, easily performed outpatient procedure which can provide a rapid diagnosis. It is eminently suitable for the investigation of superficial palpable lesio...
Zaburzenia oddychania u dzieci chrapiących w czasie snu, w świetle badań polisomnograficznych
<b>Cel pracy.</b> Określenie częstości występowania i charakteru zaburzeń oddychania podczas snu u dzieci chrapiących.<br><b>Materiał i metody.</b> 10...
Precancerous conditions in gynecology
Precancerous conditions in gynecologic oncology are the changes where malignant neoplasms occur more frequently than in the healthy tissue of female genital tract.Vulvar and vaginal precancerous leasions occure in any ag...