Our Autoimmune Hepatitis Patients: Single Center Experience
Journal Title: Istanbul Medical Journal - Year 2020, Vol 21, Issue 2
Abstract
Introduction: Autoimmune hepatitis (AIH) is a form of chronic hepatitis of unknown etiology characterized by autoimmunological properties and circulating autoantibodies. It can be treated after early diagnosis and often requires a great effort during diagnosis and regular follow-up. In Turkey, the number of studies examining AIH patients from the point of diagnosis to treatment is very low. We retrospectively evaluated patients diagnosed with AIH in the last 10 years. Methods: Between 2009 and 2019, AIH patients who were diagnosed in our hospital or applied for ongoing treatment were evaluated retrospectively from the hospital information system. Patients who responded were invited to the clinic and missing data were added. Results: A total of 48 patients (10 males and 38 females) aged 18-73 years (44.8±14.8 years) were evaluated. Four patients (8.3%) were asymptomatic. In the pre-treatment evaluation, cirrhosis occurred in 31% of patients, acute hepatitis in 21% of patients, and chronic hepatitis in 39% of patients. Type 1 AIH was observed in 81.2% of patients, 4.2% had type 2 AIH, and 14.6% demonstrated autoantibody negative AIH. A total of 35.4% of patients (n=17) had overlap syndrome accompanied by biliary tract damage. A total of 68.8% of patients with type 1 AIH had antinuclear antibody, 41.7% were positive for anti-smooth muscle antibody, and 31.3% were positive for both autoantibodies. A total of 33.3% of patients had non-hepatic disease. The treatment response rates were: 68.8% (complete); 18.7% (partial); and 12.5% (non-responders). Of the patients with a mean follow up of 3.54±2.63 years, 37 patients continued the treatment. Conclusion: Our data demonstrated similar findings to previously published literature in terms of the ratio of female-to-male presentation, type 1, type 2 rates, rate of concomitant non-hepatic autoimmune disease, and response to treatment. They were different in terms of the low number of asymptomatic patients, lower percentage autoantibodies, and high proportion of overlap syndrome.
Authors and Affiliations
Osman Özdoğan, Serkan Yaraş
Keywords
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- EP ID EP685073
- DOI 10.4274/imj.galenos.2020.23427
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