Outcome of Omani Women with Breast Cancer-associated Brain Metastases Experience from a University Hospital
Journal Title: Oman Medical Journal - Year 2019, Vol 34, Issue 5
Abstract
Objectives: Breast cancer (BC) is the leading cancer among women. Almost 20% of patients develop brain metastases (BM) and die shortly afterward. There is a dearth of data on the survival outcome of BC patients with BM from the Arab world. Methods: Consecutive women diagnosed with BC who developed radiologically-confirmed BM during their illness were identified through the hospital’s electronic patient’s records. Clinicopathological features and treatment outcomes were recorded. Survival was calculated using the Kaplan-Meier method, and factors affecting survival were studied using log-rank analysis. Results: Between January 2003 and June 2015, a total of 692 patients were treated for BC at our institute. Forty-eight (6.9%) developed BM. The median age at the diagnosis of BM was 45.2 years. More than half of cohort (54.2%) had HER2 positive disease, while 27.1% had the triple-negative disease. The median time interval between the diagnosis of BC and the development of BM was 21 months, and median survival after development of brain disease was seven months. On univariate analysis, pathological grade, previous systemic treatment, brain as the first site of metastases, brain as the only site of metastases, treatment of BM, systemic treatment after BM, and diagnosis-specific graded prognostic assessment (DS-GPA) score significantly affected survival. On multivariate Cox regression analysis, the brain as the first site of metastases, treatment for brain disease, treatment type, and DS-GPA score significantly affected survival post-BM. Conclusions: Our data indicate that Omani women are diagnosed with BC at a younger age, develop BM earlier, and carry a poor outcome.
Authors and Affiliations
Khawaja F. Zahid, Shiyam Kumar, Khalid Al-Bimani, Tanweer Ahmed, Adil Al-Ajmi, Ikram A. Burney, Mansour Al-Moundhri
Keywords
Related Articles
- EP ID EP634686
- DOI 10.5001/omj.2019.76
- Views 66
- Downloads 0
Impact of Blood Transfusion on Troponin I Levels and Outcomes after Cardiac Surgery: A Cohort Study
Objectives: Increased cardiac troponin I (TI) has been suggested to be a sensitive indicator of intraoperative myocardial injury. We investigated the association of transfusion on TI levels post-surgery and outcomes in p...
An Unusual Case of Cardiac Mass
A 71-year-old male initially presented with history of greenish discharge from the skin over the site of an implanted pacemaker. He had a medical history of hypertension, dyslipidemia, carotid sinus hypersensitivity stat...
Lemierre’s Syndrome
Lemierre’s syndrome is a rare, life-threatening condition, which may be fatal if not properly treated. This disease refers to thrombophlebitis of the internal jugular vein, which is the result of bacterial sore throat in...
Primary Health Care in Oman: Shaping the Future
The success of any health care system in any part of the world depends entirely on the strength and reliability of its primary health care (PHC) system. It is the first portal of entry for patients to the health care sys...
Extreme Thrombocytosis in a Child: Laboratory Approaches and Diagnostic Challenges
Thrombocytosis in children as well as in adult is defined as platelet count ≥ 450 × 109/L, and it is usually a reactive feature to various medical disorders. However, extreme thrombocytosis (platelet count ≥ 1000 × 109/L...