Ovarian Granulosa Cell Tumors: A Retrospective Study of 21 Cases and a Review of the Literature
Journal Title: World Journal of Gynecology & Womens Health (WJGWH) - Year 2018, Vol 1, Issue 2
Abstract
Background: Granulosa cell tumors are rare tumors with a relatively favorable prognosis. The aim of this study was to report the epidemiologic, anatomo-clinical characteristics and to determine treatment modalities and survival rates. Methods: We retrospectively analyzed data from patients treated for granulosa cell tumors in our hospital over a 17-year period (1998-2015). Results: Twenty-one cases were retrieved. The median age was 52 years. The most common clinical manifestations at diagnosis were post-menopausal bleeding and pelvic pain. Mean tumor size was 10 cm. 76.2% of the patients were diagnosed with a stage I disease. One patient (4.8%) underwent unilateral salpingo-oophorectomy, 4 patients (19%) underwent a total hysterectomy with unilateral salpingo-oophorectomy, while 15 patients (71.4%) underwent a total hysterectomy with bilateral salpingo-oophorectomy. One patient had only a biopsy. Relapse rate was 14.3% and the latest recurrence was seen 60 months after surgery. Actuarial 10-year relapse free survival (RFS) and overall survival (OS) were 85.7% and 90.5% respectively. Conclusion: Granulosa cell tumor of the ovary is an uncommon neoplasm. The adult form progresses slowly and is often diagnosed in an early stage of disease. Surgery is the mainstay of treatment. A prolonged post-therapeutic follow-up is necessary because very late recurrences have been reported.
Authors and Affiliations
Imtinane Belaid
Keywords
Related Articles
- EP ID EP587560
- DOI 10.33552/WJGWH.2018.01.000506
- Views 145
- Downloads 0
Combined Use of Cerclage, Obstetric Pessary, and Micronised Progesterone in Recurrent Miscarriage
In recent years, the use of progesterone, cerclage, and obstetric pessaries in patients with cervical incompetence has been studied extensively. However, there have not been any published repor...
Management Strategy Change of Endometrial Hyperplasia
Endometrial hyperplasia refers to irregular proliferation of endometrial glands, combined with an increased proportion of gland and mesenchyme. This kind of disease generally results from reprodu...
Chromosome 16 Mutations and Congenital Genitourinary Malformations
Posterior urethral valve (PUV) disorder is an obstructive anomaly of the genitourinary tract. Found only in males, this condition is caused by an obstructing membrane in the posterior...
Maternal and Perinatal Outcome Among Pregnant Women with Thrombocytopenia Attending Ibrahim Malik Teaching Hospital- Sudan
Thrombocytopenia is encountered in 7-8% of all pregnancies. Thrombocytopenia is second to anemia as the most common hematological abnormality during pregnancy [1-2...
Should Labor be Routinely Induced from 39 Weeks of Gestation?
Extended delay in the onset of spontaneous labor at term continues to be a concern of practicing obstetricians due to the potential neonatal complications of post-maturity. The perinatal mor...