Ox LDL and its Correlation with HbA1C in Newly Diagnosed T2DM Patients
Journal Title: Harsukh Educational Charitable Society International Journal of Community Health and Medical Research - Year 2018, Vol 4, Issue 3
Abstract
Background: Routine lipid profile fails to explain morbidity and mortality due to cardiovascular complications of Type 2 Diabetes Mellitus (T2DM) and its need of hour to find statistically and metabolically better parameter to assess risk of cardiovascular diseases (CVD) in T2DM. Aims and Objectives: To evaluate values of oxidized Low Density Lipoproteins (ox LDL) in T2DM and find its correlation with glycated hemoglobin (HbA1C). Materials and Methods: 80 newly diagnosed T2DM patients and equal number of age and gender matched healthy individuals were included in the study. Ox LDL along with routine lipid profile, fasting and post prandial blood sugar (FBG & PPBG)) and HbA1c were estimated in all subjects. Results: The values of FBG, PPBG, triglycerides (TG), total cholesterol (TC), low density lipoproteins(LDL), very low density lipoproteins(VLDL), ox LDL and HbA1c were significantly (p<0.001) higher in newly diagnosed diabetic cases as compared to controls. In newly diagnosed T2DM cases, HbA1c had strong positive correlation with TG, TC, LDL, VLDL, oxLDL (r=0.895, r=0.921, r=0.881, r=0.895, r=0.788, respectively) and a strong negative correlation with HDL (r=-0.578). Conclusions: ox LDL shows a strong correlation with HbA1C and is metabolically a better parameter than routine lipid profile. In our study oxLDL is significantly increased in newly diagnosed T2DM patients and its increased levels are proven risk factor of CVD in T2DM patients. We concluded that ox LDL is a promising risk marker for atherosclerosis. It can help in the prompt and early detection of CVD in T2DM patients.
Authors and Affiliations
Gaurav Kumar Bansal, Sanjeev Kumar Bansal, Poonam Mahla, PK Dandona, Busi Karunanand
Keywords
Related Articles
- EP ID EP492423
- DOI -
- Views 92
- Downloads 0
Post Operative Incidents Reporting In Patients- A Clinical Study
Background: Evaluating the errors helps us to learn, identify and solve a major problem in health care systems, also this systematic approach does not intend to punish or blame individual personnel. The present study was...
Usefulness of USG in detection of hepatic lesions- A clinical study
Background: Ultrasound is easily accessible and does not expose patients to ionizing radiation. The study was done to assess the sensitivity and specificity of USG in determination of hepatic masses. Materials & Methods:...
Depression In Physicians-In-Training and its association with screen time and duration of sleep a Cross-sectional Study
Background: This study is done to understand prevalence and factors associated depression in physicians-In training. There is a need to understand if depression in medical students is associated with risk factors like us...
Assessment Of Correlation Of Type Of Gallstones With The Type Of Mucosal Response In Patients Undergoing Laparoscopic Cholecystectomy
Background: Gallstones are hardened deposits of the digestive fluid bile that can form within the gallbladder. The gallbladder mucus plays a regulatory role in cholelithiasis as it promotes the nucleation of stones. Mucu...
Comparative evaluation of efficacy of Two-port mini laparoscopic cholecystectomy and standard four-port laparoscopic cholecystectomy: A clinical study
Background:Preliminary reports on the performance of LC suggest that the increased rate of intraoperative complications is attributed to technical diffHence; under the light of above mentioned data, we planned the pres...