OX40 Gene and Serum Protein Expression Profiles in Patients with Parkinson’s Disease
Journal Title: Cell Journal(Yakhteh) - Year 2018, Vol 20, Issue 2
Abstract
Objective: Inflammation of the immune system and the central nervous system has been known as an important predisposing factor for Parkinson’s disease (PD). Increased expression of OX40 protein (CD134) is a known factor for increased inflammation and initiation of NF-kappa-B signaling pathway in different diseases. We aimed to investigate the expression of OX40 at the transcript and serum protein levels. Materials and Methods: Twenty individuals with PD and 20 healthy individuals, as controls, were enrolled in this casecontrol study. Expression of OX40 at the transcript level and serum protein levels were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assays respectively. Results: The mean expression level of OX40 was increased in patients but not at a significant level (P>0.05). Consistently, the mean serum concentration of OX40 showed a mild, but non-significant, increase in the patients (P>0.05). Conclusion: We conclude that OX40 expression at either the transcript or protein level has no diagnostic utility in asymptomatic PD. This shows the need for clinical, cellular and interventional research to detect new robust biomarkers.
Authors and Affiliations
Azadeh Seyedjoodaki, Fereshteh Alsahebfosoul, Nahid Eskandari, Vahid Shaygannejad, Mansour Salehi, Mohammad Kazemi, Mostafa Manian, Omid Mirmosayyeb
Keywords
Related Articles
- EP ID EP508871
- DOI 10.22074/cellj.2018.5038
- Views 202
- Downloads 0
Transplantation Of Autologous Bone Marrow Mesenchymal Stem Cells With Platelet-Rich Plasma Accelerate Distraction Osteogenesis In A Canine Model
Objective: Distraction osteogenesis (DO) is a surgical procedure used to generate large volumes of new bone for limb lengthening. Materials and Methods: In this animal experimental study, a 30% lengthening of the left ti...
Association Of The Common CYP1A1*2C Variant (Ile462Val Polymorphism) With Chronic Myeloid Leukemia (CML) In Patients Undergoing Imatinib Therapy
Objective Cytochrome P450 is one of the major drug metabolizing enzyme families and its role in metabolism of cancer drugs cannot be less emphasized. The association be- tween single nucleotide polymorphisms (SNPs) in CY...
Comparison Of The Expression Of MiR-326 Between Interferon Beta Responders And Non-Responders In Relapsing-Remitting Multiple Sclerosis
Objective Multiple sclerosis (MS) is an inflammatory disease resulting in demyelination of the central nervous system (CNS). T helper 17 (Th17) subset protects the human body against pathogens and induces neuroinflammati...
Stochastic Cell Fate and Longevity of Offspring
Objective: Cellular decision-making is a key process in which cells with similar genetic and environmental background make dissimilar decisions. This stochastic process, which happens in prokaryotic and eukaryotic cells...
Melatonin Attenuates Upregulation of Duox1 and Duox2 and Protects against Lung Injury following Chest Irradiation in Rats
Objective: The Lung is one of the most radiosensitive organs of the body. The infiltration of macrophages and lymphocytes into the lung is mediated via the stimulation of T-helper 2 cytokines such as IL-4 and IL-13, whic...