Oxidants and antioxidants of erythrocytes
Journal Title: Progress in Health Sciences - Year 2014, Vol 4, Issue 1
Abstract
Erythrocytes contain reactive forms of oxygen (superoxide anion, hydrogen peroxide, hydroxyl radical) and reactive form of nitrogen (nitric oxide anion, S-nitrosothiols, peroxynitrite anion). Reactive oxygen species and reactive nitrogen species inactivate enzymatic (methemoglobin reductase, Cu, Zn-Superoxide dismutase, catalase, glutathione peroxidase) and non-enzymatic (glutathione, alpha-tocopherol, beta-carotene, ascorbate) antioxidants. Their quantity in erythrocytes increases in case of exposure to xenobiotics, in erythrocytes containing pathological hemoglobin, in erythrocytes with the enzymatic defects of the glycolytic or pentose cycle, in erythrocytes found in arterial and venous thrombi, and in the blood extravasated to tissues and body cavity. In such cases are observed in erythrocytes: structure modification of hemoglobin and membrane proteins, and lipids peroxidation. These processes cause changes of shape, decrease of flexibility, decrease of resistance to hemolysis, Heinz's bodies production and shorten the life span of red cells.
Authors and Affiliations
R Łapiński, M Siergiejuk, A Worowska
Keywords
Related Articles
- EP ID EP75277
- DOI -
- Views 122
- Downloads 0
Vision problems in children - a review
<b>Introduction</b>: A vision problem is a condition which involves not only visual difficulty but also blindness.
Clinical and videocapillaroscopic features and serum concentration of nitric oxide in patients with Raynaud’s phenomenon after Multiwave Locked System laser therapy
Purpose: The aim of the study was the assessment of the influence of MLS laser therapy on morphological changes in nailfold videocapillaroscopy (NVC), clinical features, and the serum NO level in patients with primary an...
Cardio-respiratory status of stone grinders and brick field workers from west Bengal, India
Introduction: Quartz crushing and brick making industry are informal and demands heavy manual labour. They are socio-economically backward and are unable to avail of social security’s scheme meant for protection of...
Male circumcision under Polish criminal law
Introduction: Male circumcision is not widely discussed in Poland. This article is the first paper on circumcision in the light of Polish criminal law and anticipates a problem that can happen in the practice of the Poli...
Effect of a medicinal agent, possessing antioxidant and antihypoxant properties, on the state of oxygen homeostasis and lipid peroxidation under experimental pneumoconiosis in albino rats
Introduction: Pneumoconioses (Pc) are interstitial pulmonary diseases of professional genesis, caused by long-term inhalation of high dust concentrations. Pcafflict 26.6-53% of the workers, exposed to dust contamination....