Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke) The role of Ginkgo biloba extract
Journal Title: Sultan Qaboos University Medical Journal - Year 2012, Vol 12, Issue 2
Abstract
Tis study aimed to investigate the presence of oxidative stress and inflammation in ischaemic stroke patients by measuring malondialdehyde (MDA), total antioxidant status (TAS), and highlysensitivity C-reactive protein (hsCRP) in the early post-ischaemic period, and to determine the role of Ginkgo biloba therapy in correcting the markers of oxidative stress and inflammation. Methods: Tis study was conducted at Ibn Seena Hospital, Mosul City, Iraq and included 31 cerebrovascular accident (CVA) patients and 30 healthy controls. Ischaemic stroke patients were divided into two groups: group I (n = 15) received conventional therapy; group II (n = 16) received conventional therapy with G. biloba (1500 mg/day) for 30 days. Blood samples were obtained from patients and controls before treatment and assays done of serum levels of MDA, TAS, and hsCRP. For CVA patients, a post-treatment blood sample was taken and the same parameters reassessed. Results: Compared with the controls, patients’ serum levels of MDA, and hsCRP were signifcantly higher (P ≤0.001) and TAS signifcantly lower. Group I and II patients reported a signifcant reduction in serum levels of MDA and hsCRP and a signifcant increase in serum levels of TAS, in comparison with pre-treatment levels. Tere was no signifcant difference (P = 0.19) in serum MDA levels between groups I and II, whereas, serum TAS levels were signifcantly higher (P ≤0.01) and hsCRP signifcantly lower (P ≤0.01) in group II. Conclusion: Acute stroke is associated with oxidative stress and inflammatory response in the early period. G. biloba plays a potential role in reducing oxidative damage and inflammatory response.
Authors and Affiliations
Imad A-J Tanoon| College of Medicine, University of Mosul, Mosul, Iraq, Hilmy AS Abdul-Jabbar| Neurosurgery Unit, Iben Seena Hospital, Mosul, Iraq, Dhia A Taha| Sharkat General Hospital, Salah Al-Din Health Institute, Salah Al-Din, Iraq
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