Oxidative stress and enzymatic antioxidant status of blood and synovial fluid in rheumatoid arthritis patients
Journal Title: Annales Academiae Medicae Silesiensis - Year 2016, Vol 70, Issue
Abstract
INTRODUCTION: Although the exact etiology of rheumatoid arthritis (RA) remains unknown, there is increasing evidence that reactive oxygen species (ROS) and oxidant/antioxidant imbalance are an important part of the pathogenesis of joint tissue injury. MATERIAL AND METHODS: The activities of: manganese superoxide dismutase (MnSOD) and copper-zinc superoxide dismutase (CuZnSOD) isoenzymes, catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST), and malondialdehyde (MDA) levels were determined in blood and synovial fluid samples from 178 RA patients and from 27 healthy controls. RESULTS: The RA patients showed increased antioxidant enzyme activities and MDA levels. Decreased synovial fluid viscosity was associated with a tendency for a changed antioxidant system with increased antioxidant enzyme activities, thereby suggesting a possible adaptation to ROS production in the blood and synovial fluid in RA patients. CONCLUSIONS: Correlating antioxidant enzyme activities and MDA levels to disease activity might provide further information about oxidative stress in RA pathogenesis.
Authors and Affiliations
Alina Ostałowska, Bogdan Koczy, Ludmiła Słowińska, Aleksandra Kasperczyk, Michał Dobrakowski, Urszula Błaszczyk, Tomasz Stołtny, Ewa Birkner, Sławomir Kasperczyk
Keywords
Related Articles
- EP ID EP365259
- DOI 10.18794/aams/63509
- Views 69
- Downloads 0
Rs2058539 and rs10953505 visfatin gene polymorphisms their plasma concentrations and occurrence of overweight and obesity among patients reporting to primary healthcare clinic
INTRODUCTION: Visfatin is a newly discovered adipocytokine displaying insulino-mimetic properties. The role of the investigated polymorphisms in visfatin coding genes and their blood plasma levels in the development of i...
The influence of chocolate on human health
Recent research confirms the healthy properties of chocolate. However, the history of cocoa as a drug dates back several thousand years. The cocoa tree growing in the equatorial climate in the beliefs of the ancient Maya...
Wpływ polimorfizmu rs1421085 genu FTO na rozwój nadciśnienia tętniczego u osób z nadwagą i otyłością
CEL PRACY: Celem pracy było znalezienie związku między polimorfizmem rs1421085 genu FTO a występowaniem nadciśnienia tętniczego u osób z nadwagą i otyłością. MATERIAŁ I METODYKA: Badaniem objęto łącznie kolejnych 391 pac...
Age-related alterations in arginase-NO-synthase system in patients with coronary heart disease associated with hypertension
INTRODUCTION: Coronary heart disease (CHD) is the most common heart diseases in Europe. The aim of this study was to determine the intensity of L-arginine metabolism by two alternative pathways (oxidative by NOS and nono...
Wpływ wczesnych zakażeń na ekspresję molekuł CD11a, CD11b, CD11c, CD18, CD54 i CD62L na powierzchni neutrofili i monocytów obwodowej krwi żylnej u wcześniaków
WSTĘP: Molekuły adhezji komórkowej na neutrofilach i monocytach odgrywają ważną rolę w odporności nowo-rodków. MATERIAŁ I METODY: U 82 wcześniaków (47 z zakażeniem wczesnym i 35 bez zakażeń; 37 płci męskiej i 45 żeńskiej...