Oxidative stress and enzymatic antioxidant status of blood and synovial fluid in rheumatoid arthritis patients
Journal Title: Annales Academiae Medicae Silesiensis - Year 2016, Vol 70, Issue
Abstract
INTRODUCTION: Although the exact etiology of rheumatoid arthritis (RA) remains unknown, there is increasing evidence that reactive oxygen species (ROS) and oxidant/antioxidant imbalance are an important part of the pathogenesis of joint tissue injury. MATERIAL AND METHODS: The activities of: manganese superoxide dismutase (MnSOD) and copper-zinc superoxide dismutase (CuZnSOD) isoenzymes, catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST), and malondialdehyde (MDA) levels were determined in blood and synovial fluid samples from 178 RA patients and from 27 healthy controls. RESULTS: The RA patients showed increased antioxidant enzyme activities and MDA levels. Decreased synovial fluid viscosity was associated with a tendency for a changed antioxidant system with increased antioxidant enzyme activities, thereby suggesting a possible adaptation to ROS production in the blood and synovial fluid in RA patients. CONCLUSIONS: Correlating antioxidant enzyme activities and MDA levels to disease activity might provide further information about oxidative stress in RA pathogenesis.
Authors and Affiliations
Alina Ostałowska, Bogdan Koczy, Ludmiła Słowińska, Aleksandra Kasperczyk, Michał Dobrakowski, Urszula Błaszczyk, Tomasz Stołtny, Ewa Birkner, Sławomir Kasperczyk
Keywords
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- EP ID EP365259
- DOI 10.18794/aams/63509
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