Oxidative Stress, Antioxidant Status and Hs-CRP Levels in Essential Hypertension
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Essential hypertension may lead to severe complication and causes the problems like cardiovascular risk in humans. Increased level of serum cholesterol, TAG, has been observed in patients with hypertension. This study intends to know the levels of oxidative stress, antioxidant status and hsCRP levels in essential hypertensive patients. Totally 160 subjects between 35–55 years age group were included in the study.115 healthy subjects were considered as Essential Hypertension with blood pressure 140/90mmHg and 45 as healthy controls. Patients with secondary hypertension, past history of stroke, coronary artery disease, myocardial infarction, and diabetes mellitus were excluded. Serum lipid profile, total antioxidant status and thiobarbituric acid reactive substances,hsCRP were estimated in these patients by standard procedures and the values were compared with healthy controls. Our study shows that significant increase in TBARS levels and Lipid profile in HTN patients, whereas HDL-C, antioxidants, was decreased among hypertensive compared to controls. CRP levels were significantly increased in hypertensive patients when compared to control group. Increasing level of HsCRP leads to cause risk of CVD. Lipid profile, TBARS and CRP levels were significantly raised in HTN patients compare to controls. Thus, monitoring lipid level and maintaining oxidative balance in hypertensive patients would be helpful in preventing the diseases associated with hypertension.
Authors and Affiliations
Nakkeeran . M, Periasamy . S, Inmozhi Sivakamisundari . R, Ramya . P, Kanagasabai . G
Keywords
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- EP ID EP598609
- DOI 10.9790/0853-160307100103.
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