Oxidative stress during spontaneous vaginal delivery: comparison between maternal and neonatal oxidative status
Journal Title: International Journal of Medical Research and Review - Year 2016, Vol 4, Issue 1
Abstract
Introduction: Spontaneous vaginal delivery inflicts a change in the redox status of the mother and the neonate. Hypoxia followed by reperfusion during powerful labour contractions causes increased generation of free radicals affecting the maternal oxidative status. The difference that exists between the extra uterine and intra uterine environment in the partial pressures of oxygen can induce free radical formation which affects the antioxidant mechanism of the neonate during vaginal delivery. The present study was aimed at quantifying the changes with respect to oxidative stress that occurs in uncomplicated laborin both the mother and newborn. Method: 20 singlet on term pregnant women in labour without any complications, delivered by spontaneous vaginal delivery were included in our study. Estimation of plasma MDA (Malondialdehyde) as a marker of lipid peroxidation and antioxidants like SOD (Superoxide dismutase), Total reduced Glutathione (GSH), and Glutathione Peroxidase (GPX) in hemolysate were performed using spectrophotometric method from cord blood and women in labour respectively. Result: The results showed significantly elevated plasma MDA in cord blood compared to maternal plasma MDA, before (P<0.001) and after delivery (P<0.001). Statistically significant higher GSH levels in the cord blood was observed compared to maternal GSH levels both before (P <0.05) and after delivery (P< 0.05). Maternal GPX level was significantly elevated when compared to cord (P< 0.05). However, SOD levels did not show any significant change. Conclusion: Vaginal delivery predisposes the neonate to increased oxidative stress when compared to maternal system which is reflected as an alteration in their antioxidant levels.
Authors and Affiliations
Chitra M,, Mathangi D, C, Priscilla Johnson
Keywords
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