Oxidative stress induced damage in benign and malignant breast diseases: histopathological and biochemical aspects
Journal Title: Журнал ÑтреÑÑ-физиологии и биохимии - Year 2012, Vol 8, Issue 1
Abstract
Increasing evidences indicate involvement of free radicals in the pathogenesis of benign and malignant breast diseases. Free radicals are highly reactive molecules and react with non–radicals in chain reaction leading to formation of new free radicals. If the defense mechanism of body fails to combat them, these free radicals pose a threat of injuring tissues by reacting with cell lipids. Lipids in the cell membrane undergo degradation to form hydroperoxides, which decompose to form a variety of products including malondialdehyde (MDA). MDA therefore was used as a marker to assess oxidative damage of cells and tissues. The aim of the present study was to assess the status of oxidative stress in the patients of benign and malignant breast diseases. Study has been made on the blood samples of 25 cases of benign breast disease and on an equal number of breast carcinoma patients. 20 healthy subjects were taken as the control cases. Mean MDA levels were significantly raised with depletion of antioxidant activity in all the patients in comparison to their control group suggesting the role of oxidative damage in the aetiopathogenesis of disease.
Authors and Affiliations
Khanna Seema, Deepti Pande, Reena Negi, Kanchan Karki, Ranjana Khanna, H Khanna
Keywords
Related Articles
- EP ID EP92644
- DOI -
- Views 118
- Downloads 0
Pre-exposure to gamma rays alleviates the harmful effect of salinity on cowpea plants
Soil salinity is one of the most severe factors limiting growth and physiological response in cowpea plants. In this study, the low concentrations of NaCl (25mM) increased plant growth, photosynthetic pigments content, t...
Studying the Relationship Between Climatic Factors and Cotton Production by Different Applied Methods
This study investigates the statistical relationship between climatic variables and aspects of cotton production (G. barbadense), and the effects of climatic factors prevailing prior to flowering o...
Monitoring the sensitivity of selected crops to lead, cadmium and arsenic
Heavy metals are highly toxic environmental pollutants. In plants, these compounds cause numerous slighter or stronger toxic effects. They inhibit root and shoot growth and yield production, affect nutrient uptake...
Evaluation of PAL activity, Phenolic and Flavonoid Contents in Three Pistachio (Pistacia vera L.) Cultivars Grafted onto Three Different Rootstocks
Phenylalanine ammonia lyase (PAL) is a biochemical marker of the environmental stress and plays a pivotal role in phenolic synthesis. The lower ROS level and oxidative damage was observed in grafted plants and the rootst...
Enzyme activity, hormone concentration in tree shrew (Tupaia belangeri) during cold acclimation
Environmental factors play an important role in the seasonal adaptation of body mass and thermogenesis in wild small mammals. The tree shrew ([i]Tupaia belangeri[/i]), is a unique species of small mammals which is origin...