Oxidative stress induced damage in benign and malignant breast diseases: histopathological and biochemical aspects
Journal Title: Журнал ÑтреÑÑ-физиологии и биохимии - Year 2012, Vol 8, Issue 1
Abstract
Increasing evidences indicate involvement of free radicals in the pathogenesis of benign and malignant breast diseases. Free radicals are highly reactive molecules and react with non–radicals in chain reaction leading to formation of new free radicals. If the defense mechanism of body fails to combat them, these free radicals pose a threat of injuring tissues by reacting with cell lipids. Lipids in the cell membrane undergo degradation to form hydroperoxides, which decompose to form a variety of products including malondialdehyde (MDA). MDA therefore was used as a marker to assess oxidative damage of cells and tissues. The aim of the present study was to assess the status of oxidative stress in the patients of benign and malignant breast diseases. Study has been made on the blood samples of 25 cases of benign breast disease and on an equal number of breast carcinoma patients. 20 healthy subjects were taken as the control cases. Mean MDA levels were significantly raised with depletion of antioxidant activity in all the patients in comparison to their control group suggesting the role of oxidative damage in the aetiopathogenesis of disease.
Authors and Affiliations
Khanna Seema, Deepti Pande, Reena Negi, Kanchan Karki, Ranjana Khanna, H Khanna
Keywords
Related Articles
- EP ID EP92644
- DOI -
- Views 134
- Downloads 0
Phenotypic Traits of Arabidopsis Plants Deficient in RpoTmp RNA Polymerase
In Arabidopsis, three nuclear-encoded RNA polymerases participate in the transcription of organellar genes. RpoTmp is a RNA polymerase that localizes both in mitochondria and chloroplasts, but is involved predominantly...
АКТИВНОСТЬ НИТРАТРЕДУКТАЗЫ У ОЗИМОЙ ПШЕНИЦЫ ПРИ ТЕПЛОВОМ ШОКЕ
Нитраты является основным источником азота для большинства растений. Поглощение и превращение нитратов в растениях во многом определяются внешними условиями и в, первую очередь, температурой и освещённостью. Изучали влия...
Effect of Crude Brassinosteroid Extract on Growth and Biochemical Changes of Gosssypium hirsutum L. and Vigna mungo L.
The present study was aimed to examine the influence of BRs on seed germination and seedling growth in [i]Gossypium hirsutum[/i] L. Var Svpr 2 and [i]Vigna mungo[/i] (L.) Hepper Var T9. The application of BRs on seed ge...
Study of photosynthesis process in the presence of low concentrations of clomazone herbicide in tobacco (Nicotiana tabacum)
The effect of chemical residues of clomazone on photosynthetic processes has been studiedby using several low concentrations of the herbicide (0, 1, 0.1, 0.01, 0.001, 0.0001 and 0.00001) µM and seedlings of two varie...
Brassinosteroids Denigrate the Seasonal Stress through Antioxidant Defense System in Seedlings of Brassica juncea L.
The present work has been undertaken to study the effect of exogenously application of 24-epiBL and 28-homoBL on soluble protein, proline contents and antioxidant defense system of Brassica juncea L. RLM 619 under the in...