Oxidative Stress, Inflammation And Apolipoprotein B (Apo B): Risk Indicators of Cardiovascular Disease in Non Diabetic Obese Males
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Background and Objectives: Obesity is associated with dyslipidemia, altered apolipoprotein levels and chronic inflammation. The inflammatory markers (IL-1, TNF-alpha) in turn induce oxidative stress and hepatic synthesis of fibrinogen which is an active phase reactant and hence a marker of active inflammation in obesity. The increased levels of plasma fibrinogen lead to a hypercoagulable state inducing atherosclerosis and cardiovascular disease. Hence, this study was designed to evaluate lipid profile, apolipoprotein B (Apo B), fibrinogen and oxidative stress markers in non diabetic obese males. Method: A case control study was done comprising of 45 non diabetic obese males and 45 healthy controls. Biochemical parameters measured in this study are fasting blood glucose, lipid profile (total cholesterol, triglyceride, HDL and LDL), apolipoprotein B, plasma fibrinogen, FOX2 and FRAP. Obesity expressed in terms of BMI and WHR. Results: Obesity was significantly correlated with dyslipidemia, apolipoprotein B, inflammation and oxidative stress. Conclusion: The present study identifies a pro artherogenic state in obesity as evidenced by a rise of lipid parameters, oxidative stress, Apo B and inflammatory marker.
Authors and Affiliations
Dr. Sucheta Panda, Dr. Sharmistha Swain, Dr. Srikrushna Mahapatra, Dr. Pramila Kumari Mishra, Dr. Nirupama Devi, Dr. Rasmita Padhy, Dr. Roma Rattan
Keywords
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