Oxytocin model of formation of psychotic symptoms and its implications for research on oxytocinergic pathway in schizophrenia
Journal Title: Psychiatria Polska - Year 2014, Vol 48, Issue 1
Abstract
There are more and more data to support the dysregulation of the oxytocinergic pathway in schizophrenia. The development of the above branch of knowledge began to evolve alongside the mainstream of studies concerning gene polymorphisms for dopaminergic, glutamatergic and serotoninergic systems. Both experimental studies and clinical trials have demonstrated an antipsychotic effect of oxytocin. Starting with the pioneering neuroendocrinobehavioral experiment which demonstrated that oxytocin nasal spray increases the level of trust in healthy volunteers dozens of experiments were carried out confirming the modulatory role of oxytocin for the recognition of emotion, social memory, pro-social behaviours, collaborative behaviours and behaviours that require generosity and altruism. According to ,oxytocin model’ of development of psychotic symptoms – oxytocinergic system dysregulation may affect the incorrect attribution of meaning of emotional information from the environment. This can be manifested in the form of social cognition dysfunction and leads to abnormal social behaviour as withdrawal from social contact, isolation and formulation of paranoid delusions. From the clinical psychiatry point of view it became crucially need for research on selective oxytocin receptor agonists, as they may be used in the treatment of diseases which manifest in social withdrawal, lack of trust and the absence of affiliation behaviour as in schizophrenia.
Authors and Affiliations
Justyna Holka-Pokorska, Marek Jarema
Keywords
Related Articles
- EP ID EP163082
- DOI -
- Views 83
- Downloads 0
Diagnostic imaging of lying
Functional diagnostic imaging has been applied in neuropsychology for more than two decades. Nowadays, the functional magnetic resonance (fMRI) seems to be the most important technique. Brain imaging in lying has been pe...
The influence of parents personality and DRD4 and 5HTT genes polymorphisms on predisposition to alcohol dependence in their sons
Summary Aim. The aim of this work was to investigate differences in parents’ personality and dopaminergic and serotoninergic gene polymorphisms which may affect certain predispositions to alcohol dependence as describ...
Dissociative fugue in a maternity ward patient – a case report
Summary Aim. To pay attention to the role of stress connected with delivery, obstetric history, as to the pathologies in the infant as predictors of dissociative disturbances in the patient of the maternity ward. Meth...
Propozycja formularzy zgody pacjenta na hospitalizację psychiatryczną i leczenie
The Polish medical law has accepted the rule of equivalence in the doctor-patient relationship. In this way it gave up on the medical paternalism”. To a large extent, the newly passed or renewed Rules and Regulations wer...
List do redakcji