P53 codon 72 polymorphism and its association with cervical cancer
Journal Title: International Journal of Scientific Research and Management - Year 2017, Vol 5, Issue 9
Abstract
Cervical cancer frequently associated with multiple HPV types. Recent report suggests that a polymorphism of the p53 tumor suppressor gene that results in the substitution of a proline residue with an arginine at position 72 protein, it act as a risk factor in HPV associated malignancies. The present study, we examined the genotypic frequency of this polymorphisms in 24 patients with cervical cancer using allele - specific polymerase chain reaction to detected P53 polymorphism at 72 codon. The frequency distribution of genotypes in cervical cancer patients as 29% (7tumors) for the arginine/arginine allele, 63% (15 tumors) for the heterozygous arginine/proline status, and 8% (2 tumors) for the proline/proline allele respectively. Allele fr equencies of proline and arginine at 72 codon of P53 gene in proline (0.400) and arginine (0.600) in cervcal cancer patients. Statistically significant difference was observed between the Proline/proline, arginine/arginine and proline/arginine genotypes in cervical cancer tumors (x 2 =16.125; p=0.003). In our result p53 codon72 Arg homozygosites has been associated with increased risk developing cervical cancer. The present study reports P53 codon 72 arginine homozygosity constitutes a risk factor for the dev elopment of invasive cervical carcinoma. In conclusion, the P53 arginine represents a potential risk for cervical cancer development. Key words: cervical cancer , p53,codon 72 polymorphism, HPV
Authors and Affiliations
A. Pavani Priyanka,
Keywords
Related Articles
- EP ID EP314334
- DOI -
- Views 88
- Downloads 0
An Analysis of Public Finance of Andhra Pradesh and Telangana State Pre - Bif urcation and Post - Bifurcation The Case Study From 1980 - 2016
The Public finance of Andhra Pradesh illustrates dynamic changes with reference to economic growth. The paper aims at studying trends in P ublic Revenue and Expenditure of A.P State Pre - bifu...
Secured Netbanking Using Minutiae Methodm
The main objective of this project is to avoid hacking process in an on - line banking sector by using finger print recognition technique. Minutiae is the most effective method in which the finger prints are extracted in...
A Generalized Andre Plane of order
A translation plane of order 3 4 is constructed. It is shown that the plane is a generalized Andre plane and computed the translation complement of the plane .It is fo u nd to be o f order 6400
Design and Development of a Charge-Sensitive Preamplifier for Nuclear Pulse Processing
Authors attempt to describe a Charge - Sensitive P reamplifier for fast Pulse Processing. The charge sensitive preamplifier uses a capacitor in place of the feedback resistor. The input capacitance of this circuit is C...
Brain Tumor Segmentation: A Review
Medical imaging is a technique that is extensively used to create images of human body for medical and research purposes. Magnetic Resonance Imaging (MRI) is a powerful visualization tool that permits to a...