PAEDIATRIC ACUTE MYELOID LEUKAEMIA; CLINICAL CHARACTERISTICS AND TREATMENT OUTCOME; EXPERIENCE FROM A DEVELOPING COUNTRY.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 11
Abstract
Objective: To document the demographics and treatment outcome of Paediatric Acute Myeloid Leukaemia (AML) at a tertiary care facility of Pakistan. Methods: The prospective descriptive study conducted at the Paediatric Oncology department, Combined Military Hospital (CMH) Rawalpindi, Pakistan. All newly registered cases of AML under eighteen years of age from 1st January 2012 onwards who completed their treatment before 30th September 2018 were included. Results: Data of 187 cases of De novo AML, including 117 (62.6 %) males and 70 (37.4 %) females was analysed. The mean age was 6.1 ? 3.53 years. The most common presenting features were pallor 156 (83.4%), fever 143 (76.5%) & bruising/bleeding 95 (50.8 %). Sixty-six (35.3 %) patients had WBC >50x109/L at presentation. The most common FAB subtype was M-2 in 85 (45.5 %), followed by M-4 in 25 (13.4 %) cases. The overall treatment related mortality (TRM) was 55/187 (29.4%). The major causes of TRM were neutropenic sepsis and bleeding. Sixty patients had refractory or relapsed disease and 53 (88.3%) of them also died. Total 121 patients completed full treatment. OS and DFS of these 121 patients were 65.3 % and 59.5% respectively. Conclusions: This is the largest study of Paediatric AML from Pakistan. High TRM, primarily during induction chemotherapy and relapsed/refractory disease are the major causes of treatment failure. AML-M2 has the best survival rates. Malnutrition, high WBC counts at presentation and unfavourable cytogenetics have decreased OS and DFS rates. Use of Etoposide during induction chemotherapy does not give any survival advantage.
Authors and Affiliations
Tariq Ghafoor, Imtenan Sharif, Tanveer Ashraf, Shakeel Ahmed, Farrah Bashir.
Keywords
Related Articles
- EP ID EP423090
- DOI 10.21474/IJAR01/7977
- Views 63
- Downloads 0
EFFECT OF CAFFEINATED DRINK ON LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC MALE ALBINO RATS.
Alteration of glucose metabolism has been shown to cause variation in the lipid profile. This study assesses the effects of caffeinated drink on lipid profile in the alloxan-induced diabetic male rat. We divided fifty ma...
SOLITARY FIBROUS TUMOUR OF BUCCAL MUCOSA: CLINICO-RADIOGRAPHIC, PATHOLOGIC AND IMMUNOHISTOCHEMICAL FEATURES.
Solitary fibrous tumours are spindle cell neoplasms that usually occur in the pleura and peritoneum and rarely involve the oral cavity. We report a clinical case of a 43-years old male patient with a solitary fibrous tum...
EPIDEMIOLOGY AND ENVIRONMENTAL DETERMINANTS OF BRONCHIAL ASTHMA AMONG CHILDREN IN AL-MADINA, SAUDI ARABIA.
Background: Bronchial asthma is a chronic respiratory disease characterized by the inflammation of the airways of the lungs. Worldwide, people are affected by it without distinction for ethnicity, age or gender. Its exac...
INTERCROPPING IN A TEMPERATE ENVIRONMENT FOR FORAGE PRODUCTION IN DRYLAND CONDITIONS.
The basic objective of the experiment was to determine vetch and cereal intercropping for forage yield in dryland conditions. The experiment was conducted under Tekirdag-Turkey ecological conditions during 2013-2015 year...
BACTERICIDAL AND BACTERIOSTATIC POTENCY OF SOME PHYTO-BACTERICIDES AGAINST SELECTED ESBL PRODUCING BACTERIA.
The study to investigate the bactericidal and bacteriostatic potency of some phyto-bactericides against selected ESBL producing bacteria was carried out. Methanolic leaf extracts of Chromoleana odorata, Lasianthera ofric...