PAEDIATRIC ACUTE MYELOID LEUKAEMIA; CLINICAL CHARACTERISTICS AND TREATMENT OUTCOME; EXPERIENCE FROM A DEVELOPING COUNTRY.

Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 11

Abstract

Objective: To document the demographics and treatment outcome of Paediatric Acute Myeloid Leukaemia (AML) at a tertiary care facility of Pakistan. Methods: The prospective descriptive study conducted at the Paediatric Oncology department, Combined Military Hospital (CMH) Rawalpindi, Pakistan. All newly registered cases of AML under eighteen years of age from 1st January 2012 onwards who completed their treatment before 30th September 2018 were included. Results: Data of 187 cases of De novo AML, including 117 (62.6 %) males and 70 (37.4 %) females was analysed. The mean age was 6.1 ? 3.53 years. The most common presenting features were pallor 156 (83.4%), fever 143 (76.5%) & bruising/bleeding 95 (50.8 %). Sixty-six (35.3 %) patients had WBC >50x109/L at presentation. The most common FAB subtype was M-2 in 85 (45.5 %), followed by M-4 in 25 (13.4 %) cases. The overall treatment related mortality (TRM) was 55/187 (29.4%). The major causes of TRM were neutropenic sepsis and bleeding. Sixty patients had refractory or relapsed disease and 53 (88.3%) of them also died. Total 121 patients completed full treatment. OS and DFS of these 121 patients were 65.3 % and 59.5% respectively. Conclusions: This is the largest study of Paediatric AML from Pakistan. High TRM, primarily during induction chemotherapy and relapsed/refractory disease are the major causes of treatment failure. AML-M2 has the best survival rates. Malnutrition, high WBC counts at presentation and unfavourable cytogenetics have decreased OS and DFS rates. Use of Etoposide during induction chemotherapy does not give any survival advantage.

Authors and Affiliations

Tariq Ghafoor, Imtenan Sharif, Tanveer Ashraf, Shakeel Ahmed, Farrah Bashir.

Keywords

Related Articles

CONCEPT OF MANASHARIRA ( MIND ) AND ITS APPLICATION IN MANASIKA VYADHI (PSYCHOLOGICAL DISORDER) CHIKITSA AS SATVAVAJAYA CHIKITSA.

Mind is one of nine Karana Dravyas. This is an internal instrument helping Purusa to feel happiness or sorrowfulness in this SthulaSarira. It is always associated with Purusa either in SthulaSarira (Karma Purusa) or Suks...

WHEN THE TREATMENT OF A PATHOLOGY AGGRAVATES ANOTHER.TERBINAFINE AND PSORIASIS: TWO CASES REPORT.

Terbinafine is an allylamine having an in vitro fungicidal effect on dermatophytes and fungistatic on Candida albicans. It is an agent widely used in dermatology but also in general medicine and other specialties. It is,...

THE STRATEGIES FOR ENHANCING TOURISM SMES? COMPETITIVENESS:THE CHALLENGES FACING THAILAND TOURISM SECTOR UNDER THE AEC?S LIBERALIZED TRADE IN SERVICES.

The AEC?s liberalization of trade in services brings ample opportunities and higher competition. This paper is a documentary research, adopting a meta-analysis method and narrative approach, focusing on tourism SMEs? rol...

ROLE OF EDUCATION IN EMPOWERMENT OF WOMEN AMONG THE SCHEDULED CASTES AND SCHEDULED TRIBES IN ANDHRA PRADESH.

In ancient India women enjoyed a high status in the society. They were provided educational opportunities comparable to men. The social evils like discrimination of Dalits, Purdha ,sati, enforced widowhood ,and child mar...

SYNTHESIS AND CHARACTERIZATION OF INTERPENETRATING POLYMER NETWORK OF POLY (METHYLHYDROSILOXANE) AND POLY (ACRYLONITRILE).

Interpenetrating polymer network (IPN) based on poly (Methylhydrosiloxane) and poly (Acrylonitrile) have been synthesized using benzyl peroxide as initiator and divinyl benzene as crosslinker in toluene under an inert at...

Download PDF file
  • EP ID EP423090
  • DOI 10.21474/IJAR01/7977
  • Views 60
  • Downloads 0

How To Cite

Tariq Ghafoor, Imtenan Sharif, Tanveer Ashraf, Shakeel Ahmed, Farrah Bashir. (2018). PAEDIATRIC ACUTE MYELOID LEUKAEMIA; CLINICAL CHARACTERISTICS AND TREATMENT OUTCOME; EXPERIENCE FROM A DEVELOPING COUNTRY.. International Journal of Advanced Research (IJAR), 6(11), 113-122. https://europub.co.uk/articles/-A-423090