PAEDIATRIC HODGKIN’S LYMPHOMA: A CLINICO-PATHOLOGICAL STUDY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 4
Abstract
Hodgkin's disease (HD) is a lymphoid tumor that forms less than 1% of all de novo neoplasms occurring every year worldwide. In all age groups, Hodgkin lymphoma is highly sensitive to chemotherapy and irradiation. Hence there is need for accurate histopathological reporting in conjugation with ancillary methods. We attempted to study the occurrence of Non Hodgkins lymphoma in paediatric population. The material for present study was obtained from SIMS and referred cases. The histopathology slides and paraffin blocks were reviewed. The gross examination was done carefully noting the size, shape, extent and configuration, nodularity and consistency. Eleven cases were encountered, out of which 5(45.45%) were mixed cellularity, 4(36.36%) were lymphocyte predominant and 2(18.18%) nodular sclerosis. The mean age being 10 yrs 6mts. Case distribution included 1 in 1-5yr, 2 in 5-10yrs and 8 cases in 10-15 yrs age group. It most commonly presented in 10-15yrs age group (72.72%). The younger one was 5 years old. Significant differences exist between lymphocyte predominant HL (LP-HL) and classic HL (CHL) (which includes the lymphocyte rich, nodular sclerosing, mixed cellularity, and lymphocyte depleted subtypes) in terms of natural history, the relation to Epstein-Barr virus, cell morphology, phenotype, molecular characteristics, and clinical behavior. Accurate incidence of data is important in the planning and evaluation of clinical trials. Documentation of cases, advanced diagnostic methods like IHC, cytogenetic studies and treatment modalities with close follow up is needed to achieve better statistical evaluation of the problem.
Authors and Affiliations
Chandrashekar Thotadamane Nagaraj, Girish Chandrashekar Jerabandi
Keywords
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- EP ID EP222490
- DOI 10.18410/jebmh/2015/53
- Views 78
- Downloads 0
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