Paget’s disease in Senegal : two cases of a rare disease in black african populations
Journal Title: Batna Journal of Medical Sciences (BJMS) - Year 2016, Vol 3, Issue 2
Abstract
Mr. MD is a 72-years-old man, admitted for spontaneous, permanent, crushing type pain on the pelvis above the right hip evolving for two years, without night or morning stiffness but increasing with hearing loss, temporal and parietal headache. Physical examination showed a painful hip in active and passive mobilization. Pressure on iliac spines and lower lumbar and sacrococcygeal bones was painful. The patient showed no inflammatory syndrome. Serum calcium was normal. We noted an isolated increase in alkaline phosphatase levels to 401 IU/l. Radiographs showed bilateral heterogeneous sclerosis of the iliac bone with thickening lines and almost disappearance of the right hip joint space. There was a marked thickening of the cortex on the femoral proximal third and thickening of the cranial vault. MRI showed cortical thickening of the right pelvic bone, a T1 hyper signal, and an intermediate T2 signal with fat/sat. This was pathognomonic of Paget's disease. The second patient is a 72-year-old man with no history, having intense pain on the right side of the lower limb. Physical examination showed no musculoskeletal deformity, but pain on palpation and mobilization of the right hip. Serum alkaline phosphatase (ALP) was raised to 4 times the normal range. Radiography showed cortical thickening of the ischial pubic branch, a heterogeneous sclerosis gypsy moth of the iliac wing, a steady narrowing of the femoral hip-spaced lines and thickening of the iliac ischial pubic. This aspect is pathognomonic of Paget’s disease, the patient underwent treatment with zoledronic acid intravenously at 5 mg. The outcome was favorable up to 10 months with reduced pain (VAS = 2/10) and normal PAL.
Authors and Affiliations
Ismaïla Diédhiou, Awa-Ndao Fall, Thierno-Oumar Soko, Abdou-Rajack Ndiaye.
Keywords
Related Articles
- EP ID EP680490
- DOI -
- Views 139
- Downloads 0
Towards the proposition of a new approach based on artificial neural networks : application to quality of life prediction through illness perception with chronic illness patients
Aim: Chronic illness affects many Algerians. It is possible to investigate the prediction ability of quality of life as a function to illness perception. In this study, we focus the assessment of the influence of patient...
Mise au point du traitement de diabète type 2
Introduction. Le diabète est un problème de Santé publique qui intéresse le monde entier, de par sa fréquence, son caractère ubiquitaire, ses conséquences à long terme, ainsi que le coût du traitement. Deux types de diab...
Enquête ethnobotanique sur Matricaria pubescens (DESF.) SCHULTZ (Asteraceae) auprès de la population des régions sud est d’Algérie
L'enquête ethnobotanique s'avère indispensable pour la connaissance des plantes médicinales et leurs utilisations. Une vaste connaissance de la façon d’utiliser les plantes contre les différentes maladies est fort envi...
L’asthénie en oncologie. Un symptôme marginalisé par les oncologues, handicapant silencieusement les cancéreux !
La maladie cancéreuse est parmi les plus riches pathologies en matière de symptomatologie clinique ; cela est dû au cancer lui-même (sa localisation, sa taille, son aspect, son extension etc.), à ses traitements (chimiot...
Maladie de Gaucher chez l’enfant : Approche diagnostique
La maladie de Gaucher, l'une des sphingolipidoses les plus courantes, a été la première maladie lysosomale à être traitée par une enzymothérapie substitutive. Ce traitement instauré précocement peut prévenir les complica...