Palpable Purpura in a Patient with Uncontrolled Type 2 Diabetes Mellitus: Possible Side Effect of Linagliptin
Journal Title: Istanbul Medical Journal - Year 2019, Vol 20, Issue 2
Abstract
Linagliptin is a member of “Dipeptidyl Peptidase-4” (DPP-4) inhibitors and may be preferred for certain advantages. We present a type 2 diabetes case with developed skin findings after initiation of linagliptin. A 66-year-old type 2 diabetic woman with coronary heart disease for 10 years was admitted to our clinic with dry mouth, polydipsia and polyuria. She was on metformin, acetylsalicylic acid and nitrate treatment. The physical examination was unremarkable. On admission, blood glucose was 319 mg/dL, urine ketone was negative, serum biochemistry and arterial blood gas results were within normal limits. Linagliptin was added to treatment after glycemic regulation was achieved with intensive insulin regimen. On the second day of linagliptin treatment, palpable purpuralike lesions were seen in the lower and upper extremities. Linagliptin was considered as an etiological factor. After discontinuation of linagliptin, the lesions gradually regressed. DPP-4 inhibitors may lead to some dermatological side effects due to inhibition of other DPP enzymes. To the best of our knowledge, our case is the first case in the literature to develop palpable purpura after linagliptin treatment.
Authors and Affiliations
Ömercan Topaloğlu, Bahri Evren, İbrahim Şahin
Keywords
Related Articles
- EP ID EP549094
- DOI 10.4274/imj.galenos.2018.48569
- Views 126
- Downloads 0
The Effect of Oral Isotretinoin on Bone Healing in Rabbit Rhinoplasty Model: An Experimental Study
Introduction: Since the age at which rhinoplasty is frequently performed is also the age at which acne is frequently seen, a person may be a candidate for both this surgery and isotretinoin therapy. In this study, we aim...
Radiotherapy in the Treatment of High Volume Chylous Fistula Following Hepatectomy: Case Report and Review of the Literature
Lymphatic injury is common in surgical procedures, but only 1-11% of cases present with chylous fistula. Although high volume chylous fistula is a rare condition after liver resection, serious life-threatening complicati...
Neurotoxoplasmosis in a Patient with Acquired Immunodeficiency Syndrome: Magnetic Resonance and Magnetic Resonance Spectroscopy Findings
Human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) is an important public health problem. In recent years, opportunistic infections that can develop in patients with AIDS are rapid...
Determination of Vestibulo-ocular Reflex Gain Normal Values in Children with Video Head Impuls Test
Introduction: Video head impuls test (vHIT) is used in the diagnosis of vestibular dysfunction. There is no study conducted on vHIT application and its results on children in our country. Our study aimed to examine vHIT...
Short- and Long-term Outcomes After Curative Surgery for Rectal Cancer in Patients Under the Age of Fourty Years: A Stage Based Case-match Analysis
Introduction: The aim of the study is to compare the short and long-term outcomes after curative surgery for rectal cancer in patients under the age of 40 years and over the age of 50 years. Methods: A total of 46 patie...