PANCYTOPENIA A COMMON PRESENTING FEATURE OF MEGALOBLASTIC ANEMIA.
Journal Title: PARIPEX-Indian Journal of Research - Year 2018, Vol 7, Issue 7
Abstract
Objective: Megaloblastic anemia is a common clinical condition, many patients presents as Pancytopenia turned out to be megaloblatic anemia because of Vitamin B12 and folic acid deficiency. There are limited number of studies in Indian subcontinent and few studies are available from the other parts of the worlds on the frequency of various causes of pancytopenia, to Analyze the clinicopathological profile in pancytopenia and its causes. Methodology : Prospective observational study, on 210 Subjects of pancytopenia older than 13 years, meeting inclusion criteria. The detailed clinical and laboratory workup was done including complete blood count, peripheral smear examination, serum Lactate Dehydrogenase,bone marrow aspiration, biopsy and staining with special stains. Results : In our study 210 cases of pancytopenia 116 (55.3%) were males and 94( 44.7%) females.The majority of the patients were in younger age group 13 - 30 years (64.7%). Megaloblastic anemia was the most common cause of pancytopenia in 83 (39.52%) , aplastic anemia in 57 (27%), malaria in 17 (8.09%) and hypersplenism in 16 ( 7.61%) of patients. Acute leukemia, myelodysplastic syndrome, SLE, HBV , multiple myeloma, and sepsis were uncommon. Conclusion : Megaloblastic anemia and aplastic anemia were amongst the common etiological diagnosis of pancytopenia, comprising 2/3 of all cases. Severe Anemia was more common in megaloblastic anemia. Thrombocytopenia was more common in patients of aplstic anemia, resulting bleeding manifestations.
Authors and Affiliations
Indal Kumar, Binay Kumar Singh
Keywords
Related Articles
- EP ID EP454556
- DOI -
- Views 90
- Downloads 0
Predicting the Outcome of Acute Non Variceal Upper Gastrointestinal Hemorrage Using Clinical Prognostic Factors and Endoscopic Staging.
Objective Predicting the outcome using the clinical prognostic factors and endoscopic staging to identify patients at risk of adverse outcomes after acute non variceal upper gastro intestinal hemorrhage. Methods: 100 pat...
Extraneural Ganglion Cyst of Proximal Tibio- Fibular Joint
Ganglion cyst causing compressive neuropathy in upper limbs is a common phenomenon but it is extremely rare in lower limbs. We are presenting a case of middle aged man who presented to us with complaints of lower limb ra...
A STUDY ON PERIOPERATIVE OUTCOME OF PARTURIENTS WITH MITRAL STENOSIS UNDERGOING ELECTIVE CAESAREAN SECTION UNDER EPIDURAL ANAESTHESIA
Rheumatic heart disease is the commonest cardiac disease complicating pregnancy in developing countries. Heart diseaseaccounts for 15% pregnancy related mortality. In the presence of maternal heart disease, the circulato...
MEDI-CLAIM UTILISATION PRACTICES AMONG THE PATIENTS OF PRIVATE HOSPITALS IN COIMBATORE CITY
This study aims to analyse the medi-claim utilisation practice among the private hospital patients in Coimbatore city. The study found that only 3.59% of the respondents' opined that the costs and services charged in mul...
Comparison Of Antimicrobial Susceptibility Pattern Of Biofilm Producing And Non-Biofilm Producing Staphylococci Isolated From Various Clinical Samples Of Patients From A Tertiary Care Hospital
Biofilms have great significance in medical field as they decrease susceptibility to antimicrobial agents. We tested 242 clinical isolates of staphylococci for biofilm production by Tissue culture plate method (TCP) and...