PANCYTOPENIA A COMMON PRESENTING FEATURE OF MEGALOBLASTIC ANEMIA.
Journal Title: PARIPEX-Indian Journal of Research - Year 2018, Vol 7, Issue 7
Abstract
Objective: Megaloblastic anemia is a common clinical condition, many patients presents as Pancytopenia turned out to be megaloblatic anemia because of Vitamin B12 and folic acid deficiency. There are limited number of studies in Indian subcontinent and few studies are available from the other parts of the worlds on the frequency of various causes of pancytopenia, to Analyze the clinicopathological profile in pancytopenia and its causes. Methodology : Prospective observational study, on 210 Subjects of pancytopenia older than 13 years, meeting inclusion criteria. The detailed clinical and laboratory workup was done including complete blood count, peripheral smear examination, serum Lactate Dehydrogenase,bone marrow aspiration, biopsy and staining with special stains. Results : In our study 210 cases of pancytopenia 116 (55.3%) were males and 94( 44.7%) females.The majority of the patients were in younger age group 13 - 30 years (64.7%). Megaloblastic anemia was the most common cause of pancytopenia in 83 (39.52%) , aplastic anemia in 57 (27%), malaria in 17 (8.09%) and hypersplenism in 16 ( 7.61%) of patients. Acute leukemia, myelodysplastic syndrome, SLE, HBV , multiple myeloma, and sepsis were uncommon. Conclusion : Megaloblastic anemia and aplastic anemia were amongst the common etiological diagnosis of pancytopenia, comprising 2/3 of all cases. Severe Anemia was more common in megaloblastic anemia. Thrombocytopenia was more common in patients of aplstic anemia, resulting bleeding manifestations.
Authors and Affiliations
Indal Kumar, Binay Kumar Singh
Keywords
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