Parallel Mechanisms between Placental Amyloidosis/Preeclampsia and Neurodegenerative Diseases
Journal Title: Asian Journal of Biology - Year 2017, Vol 2, Issue 4
Abstract
This short review summarizes recent studies on placenta-preeclampsia in the mother and/or intrauterine growth restriction in the child. The ideas raised here are framed within a paradigm that favors the opening of new research lines in these themes and are focused on the outlining of early investigation and/or an adequate treatment for mothers who develop the pathology. Thus, this review focuses on those studies that categorize PE in the group of pathologies defined as "conformational diseases", as a consequence of the misfolding of proteins due to endoplasmic reticulum ER stress. In this particular case, the ER stress that develops in the syncytiotrophoblast because of the oxidative stress caused in the placenta by the hypoxia that occurs as a consequence of the failure in the remodeling of endometrial arteries. This leads to an increased syncytiotrophoblast apoptosis with detachment of misfolded proteins into the maternal circulation, which in turn would be primarily responsible for the signs of preeclampsia in the mother: proteinuria, edema, and hypertension. The review also analyzes the preeclampsia-prions-placenta relationship, since the normal cell-surface protein PrPc is normally present in the plasma membrane of syncytiotrophoblast, but appears to be increased in cases of preeclampsia. However, although neurodegenerative disorders resulting from conformational changes in the prion protein from its normal cellular form, PrPc, to the infectious scrapie isoform, PrPSc are well known, limited information is available on Pr Pc and PrPSc in the ST, hence review on these proteins gains more attention in normal and pathological placenta.
Authors and Affiliations
C. Bosco, E. Díaz
Keywords
Related Articles
- EP ID EP337821
- DOI 10.9734/AJOB/2017/33756
- Views 87
- Downloads 0
Synchronization of Estrus Using Ovsynch Protocol and Fixed Timed Artificial Insemination (FTAI) in Indigenous Dairy Buffaloes: An Effective Buffalo Breeding Program in Bangladesh
Background: Estrus synchronization may be a tool to overcome silent estrus and breeding seasonality, the major factors limit the reproductive efficiency of indigenous buffalo (Bubalus bubalis) in Bangladesh. The present...
Libido Enhancement Potential of Piper guineense in Male Wistar Rats
Background: Some spices have been reported to play contributory role in enhancing male reproductive function. Aims: To determine the effect of Piper guineense consumption on some libido indices and behavioral pattern of...
Effects of Ovarian Steroids on Osteoblast Viability and Mineralization
Understanding the interactions between bone metabolism and ovarian and plasma changes induced by polycystic ovary syndrome (PCOS) is essential for the comprehension of the pathophysiological mechanisms involving these or...
Occurrence of Cassava Mosaic Disease Related to Agro-ecosystem in Farmer’s Fields located in Kongo Central Province, Democratic Republic of Congo
Aim: To assess the Cassava Mosaic Disease (CMD) pressure by analyzing its incidence, severity and gravity, and to characterize agro-ecosystems where cassava farmers’ fields are established. Place and Duration: The study...
Leaf Anatomical Characteristics and Its Heritability of Different Quinoa (Chenopodium quinoa Willd.) Genotypes as Influenced by Moderate and Severe Water Stress
Many plants can avoid the adverse effects of drought by developing special epidermal cell bladders which may serve as external water reservoirs and having small and thick-walled cells. The present investigation aimed at:...