Paraneoplastic Neurologic Syndromes: Rare But More Common Than Expected Nine Cases with a Literature Review

Journal Title: UNKNOWN - Year 2018, Vol 24, Issue 1

Abstract

Paraneoplastic neurologic syndromes (PNS) are rare disorders, which are remote effects of cancer that are not caused by the tumor, its metastasis or side effects of treatment. We had nine patients with PNS; two of our patients had limbic encephalitis, but one had autoimmune limbic encephalitis with no malignancy; two patients had subacute cerebellar degeneration; three had Stiff-person syndrome; one had Lambert-Eaton myasthenic syndrome; and the remaining patient had sensory neuronopathy. In most patients, the neurologic disorder develops before the cancer becomes clinically overt and the patient is referred to a neurologist. Five of our patients’ malignancies had been diagnosed in our clinic after their neurologic symptoms became overt. PNS are more common than expected and neurologists should be aware of the variety of the clinical presentations of these syndromes. When physicians suspect PNS, cancer screening should be conducted. The screening must continue even if the results are negative.

Authors and Affiliations

Hülya Uluğut Erkoyun, Sevgin Gündoğan, Yaprak Seçil, Yeşim Beckmann, Tülay Kurt İncesu, Hatice Sabiha Türe, Galip Akhan

Keywords

Related Articles

Medusa-like Atypical Intracerebral Vein: A Rare Case of Symptomatic Developmental Venous Anomaly

Developmental venous anomaly (DVA) is an extreme variation of the normal transmedullary vein, which is necessary for the normal venous drainage of an area of the brain. It occurs in as many as 2% of individuals. In most...

Quality of Life in Patients with Drug Resistant Epilepsy

Objective: Quality of life (QOL) is considered the main outcome in epilepsy trials, but in developing countries such as India, data available regarding QOL in drug-resistant epilepsy (DRE) are scarce. The present study w...

Download PDF file
  • EP ID EP277559
  • DOI 10.4274/tnd.05900
  • Views 87
  • Downloads 0

How To Cite

Hülya Uluğut Erkoyun, Sevgin Gündoğan, Yaprak Seçil, Yeşim Beckmann, Tülay Kurt İncesu, Hatice Sabiha Türe, Galip Akhan (2018). Paraneoplastic Neurologic Syndromes: Rare But More Common Than Expected Nine Cases with a Literature Review. UNKNOWN, 24(1), 63-69. https://europub.co.uk/articles/-A-277559