Pathogenesis of Corynebacterium diphtheriae and available vaccines: An Overview
Journal Title: Global Journal of Infectious Diseases and Clinical Research - Year 2017, Vol 3, Issue 1
Abstract
Corynebacterium diphtheriae is Gram-positive bacteria responsible for causing diphtheria in human and once regarded for high mortalities worldwide. The fatality gradually decreased with improved living standards and further alleviated when many immunization programs were introduced. Public infectious diseases have positively been controlled by vaccination, yet, the importance of vaccination usually remained unnoticed for the adults. Many of the under-development vaccines are directed towards the childhood immunization. However, numerous drug-resistant strains emerged recently that consequently decreased the efficiency of current therapeutics and vaccines, thereby obliging the scientific community to start investigating new therapeutic targets in pathogenic microorganisms. In this study, we try to put together a short information regarding pathogenesis of Corynebacterium diphtheriae and reported vaccine till the date. Furthermore, we highlighted the emerging technique for identification of new therapeutic targets.
Authors and Affiliations
Jamal Syed Babar, Tiwari Sandeep, Silva Artur, Azevedo Vasco
Keywords
Related Articles
- EP ID EP334878
- DOI 10.17352/2455-5363.000014
- Views 121
- Downloads 0
Arthroscopic treatment for Intraarticular knee infection in Hanoi Medical University Hospital
Objectives: 1) Describe the arthroscopic image of infected osteoarthritis of knee; 2) Evaluate the result of arthroscopic treatment for infected osteoarthritis of knee Patients and method: Retrospective study 33 patients...
Quorum Sensing in Bacterial Pathogenesis
Introduction: Quorum sensing (QS) in meaning word is a system of stimulus and response correlated to a fixed number of microbial Population density which make the microbes sense and awareness of the presence of bacteria...
Antibacterial Effects of Herbal Compounds against Acinetobacter baumannii Isolated from Hospital of Tehran, Iran
Increasing isolation of multidrug-resistant Acinetobacter baumannii (MDR) has been reported in worldwide and it is recently one of the most difficult nosocomial acquired gram-negative pathogens to control and treatment....
Pivmecillinam Treatment of Community-Acquired Uncomplicated Pyelonephritis Based on Sparse Data
Background: Pivmecillinam has good pharmacokinetic properties for treatment of infections in the urinary tract, and the mecillinam resistance rate in Enterobacteriaceae is very low. In a European guideline pivmecillinam...
PCR-Based Method for Rapid and Minimized Electrochemical Detection of mecA Gene of Methicillin-Resistant Staphylococcus aureus and Methicillin-Resistant Staphylococcus epidermis
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important pathogens that cause nosocomial infections. However, microbiological culture techniques take a few days to yield results; therefore, a simpl...