Pathogenesis of the Influenza Virus in Diabetes Model Mice
Journal Title: Microbiology Research Journal International - Year 2015, Vol 9, Issue 6
Abstract
When diabetes model mice and control mice were intranasally infected with the influenza virus (1 LD50), a significant higher mortality rate was observed in the diabetes model. The mortality rate became 100% at 10 days post infection. Furthermore, histopathological examination of lung tissue revealed a more enhanced inflammatory response in the diabetes model mice infected with the influenza virus. On the contrary, viral clearance from the lungs was suppressed in the diabetes model mice. The recruitment of macrophages was observed in the case of virus-infected control mice at 1 and 3 days post infection. Intriguingly, the number of macrophage in the lungs was not changed through the period of observation, thus the recruitment of macrophages in the lungs was not found in the virus-infected diabetes model mice.
Authors and Affiliations
Morihiro Ito, Hiromichi Kubota, Tamaki Takeuchi, Shanlou Qiao, Masato Tsurudome, Akio Matsuda, Machiko Nishio, Yasuhiko Ito
Keywords
Related Articles
- EP ID EP354325
- DOI 10.9734/BMRJ/2015/18799
- Views 71
- Downloads 0
Colonization Pattern of Rhodotorula sp. in Polluted Tilapia Fish Aquaria and the Risk of Rhodotorula Caused Infection
In this study, the trend of colonization of e-waste soil polluted fish aquaria by Rhodotorula sp was monitored. The aquaria containing the specie Oreochromis niloticus were polluted separately with different quantities o...
Bacteria Associated with Selected Rivers in Akure, Nigeria and their Alkysulphatase Activity/Production
Aims: To isolate, characterize and identify surfactant degrading bacteria from selected rivers in Akure, Nigeria and also to compare and quantify the biodegrading potentials of each of the bacterial isolates....
Oral Candidiasis: Complication of Concomitant Chemo-radiotherapy in Patients with Oral Squamous Cell Carcinoma
Objectives: To investigate oral candidiasis clinically and cytologically in patients with oral squamous cell carcinoma cancer before and at the end of concomitant chemo-radiation therapy and to explore its association wi...
Intestinal Dysbiosis in Systemic Inflamation and Possibilities of Its Correction with Probiotics
Aims: To estimate intestinal microbial changes and study the efficacy of probiotic preparations in systemic inflammation. Study Design: Cohort design. Place and Duration of Study: Sumy State University, Medical Institute...
Molecular Analysis of Staphylococcus aureus Infections in Trinidad and Tobago
Aims: Previous studies regarding Staphylococcus aureus in Trinidad and Tobago have so far been conducted mainly on methicillin resistant S. aureus (MRSA) isolates. Few reports are available regarding S. aureus infections...