Pathogenetic and clinical correlation of type 2 diabetes mellitus with metabolic syndrome and chronic coronary artery disease

Abstract

Background. Increase of morbidity of diabetes mellitus (DM) associated with coronary artery disease (CAD) on the background of metabolic syndrome (MS) is worrisome. It is very important to improve the diagnosis of this associated pathology and also to develop pathogenetic therapy, taking into account the specific stage of disease. The purpose of our work was to study the correlation of compensated and decompensated type 2 DM on the background of MS with chronic CAD. Materials and methods. 231 patients with MS and with or without type 2 DM and chronic CAD were examined. MS was characterized by the II–IIІ degree of obesity in all studied groups. The levels of cortisol, prolactin, free thyroxine, thyroid-stimulating hormone (TSH), lipids were evaluated in all patients, ultrasonography of the heart was performed. Results. Increase of cortisol levels, prolactin in women, TSH, change of lipids as high levels of triglycerides, very low-density lipoprotein cholesterol, at the control value of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and total cholesterol was detected in patients with metabolic syndrome, and also patients with compensated type 2 DM on the background of MS. Increase of interventricular septal thickness and left atrium anteroposterior dimension was observed in patients of this group. Increased levels of cortisol and prolactin as well as the control level of TSH were detected in patients with MS and decompensated type 2 DM as well as with or without chronic CAD. Increase of interventricular septal thickness, left ventricular posterior wall thickness, left atrium anteroposterior dimension was observed in patients of both groups according to results of ultrasonography. High level of total cholesterol, low-density lipoprotein cholesterol, triglycerides, very low-density lipoprotein cholesterol and low level of high-density lipoprotein cholesterol were observed in patients with MS and decompensated type 2 DM associated with chronic CAD compared to patients with MS and type 2 DM without chronic CAD. Conclusions. The pathogenetic and clinical relation of type 2 DM was established in MS and chronic CAD.

Authors and Affiliations

R. Ya. Dutka, N. V. Chmyr

Keywords

Related Articles

Hypothalamic Syndrome

No abstract

Non-alcoholic fatty liver disease: prevalence, etiology, pathogenesis, approaches to the dіagnosis and therapy (literature review and own data)

The article presents the modern literature data about the prevalence, etiology, pathogenesis of non-alcoholic fatty liver disease in type 2 diabetes mellitus, approaches to the diagnosis and therapy of these patients. Th...

Influence of recombinant human thyroid-stimulating hormone of and radioiodine therapy on the function of cells of innate immunity in patients with thyroid cancer

Background. The effect of radioiodine therapy (RIT) on the cytotoxic activity of NK cells and the metabolic activity of neutrophils (NF) in patients with differentiated thyroid cancer (DTC) was studied on the background...

Peculiarities of the course and frequency of clinical manifestations of polyglandular syndrome type ІІІА in patients living in the iodine deficient Ternopil region

Background. The problem of early diagnosis of endocrinopathies, such as type 1 diabetes mellitus, autoimmune thyroid disease, adrenal gland disorders on the background of other autoimmune pathologies, remains relevant. O...

Safety and Clinical Efficiency of Using Combined Preparation of Metformin Extended-Release and Glimepiride

The article explains the early use of a combination of glucose-lowering drugs that act on different stages of pathogenesis of diabetes mellitus (DM) type 2. The aim of the study was to evaluate changes in the indicator o...

Download PDF file
  • EP ID EP432672
  • DOI 10.22141/2224-0721.14.7.2018.148772
  • Views 58
  • Downloads 0

How To Cite

R. Ya. Dutka, N. V. Chmyr (2018). Pathogenetic and clinical correlation of type 2 diabetes mellitus with metabolic syndrome and chronic coronary artery disease. Міжнародний ендокринологічний журнал, 14(7), 655-660. https://europub.co.uk/articles/-A-432672