Pathogenetic and clinical correlation of type 2 diabetes mellitus with metabolic syndrome and chronic coronary artery disease
Journal Title: Міжнародний ендокринологічний журнал - Year 2018, Vol 14, Issue 7
Abstract
Background. Increase of morbidity of diabetes mellitus (DM) associated with coronary artery disease (CAD) on the background of metabolic syndrome (MS) is worrisome. It is very important to improve the diagnosis of this associated pathology and also to develop pathogenetic therapy, taking into account the specific stage of disease. The purpose of our work was to study the correlation of compensated and decompensated type 2 DM on the background of MS with chronic CAD. Materials and methods. 231 patients with MS and with or without type 2 DM and chronic CAD were examined. MS was characterized by the II–IIІ degree of obesity in all studied groups. The levels of cortisol, prolactin, free thyroxine, thyroid-stimulating hormone (TSH), lipids were evaluated in all patients, ultrasonography of the heart was performed. Results. Increase of cortisol levels, prolactin in women, TSH, change of lipids as high levels of triglycerides, very low-density lipoprotein cholesterol, at the control value of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and total cholesterol was detected in patients with metabolic syndrome, and also patients with compensated type 2 DM on the background of MS. Increase of interventricular septal thickness and left atrium anteroposterior dimension was observed in patients of this group. Increased levels of cortisol and prolactin as well as the control level of TSH were detected in patients with MS and decompensated type 2 DM as well as with or without chronic CAD. Increase of interventricular septal thickness, left ventricular posterior wall thickness, left atrium anteroposterior dimension was observed in patients of both groups according to results of ultrasonography. High level of total cholesterol, low-density lipoprotein cholesterol, triglycerides, very low-density lipoprotein cholesterol and low level of high-density lipoprotein cholesterol were observed in patients with MS and decompensated type 2 DM associated with chronic CAD compared to patients with MS and type 2 DM without chronic CAD. Conclusions. The pathogenetic and clinical relation of type 2 DM was established in MS and chronic CAD.
Authors and Affiliations
R. Ya. Dutka, N. V. Chmyr
Keywords
Related Articles
- EP ID EP432672
- DOI 10.22141/2224-0721.14.7.2018.148772
- Views 51
- Downloads 0
Vitamin D status, calcium, magnesium and parathyroid hormone levels in patients with diabetes mellitus
Background. The purpose was to investigate the levels of 25(OH)D, parathyroid hormone, ionized calcium and magnesium in patients with type 1 and type 2 diabetes mellitus (DM) by comparison to the group of healthy person...
Endogenous Peptide Apelin and Pathological Cardiac Remodeling in Hypertensive Patients with Diabetes Mellitus Type 2
The study involved 63 patients with essential hypertension and diabetes mellitus type 2. The control group consisted of 16 apparently healthy individuals. Complex of examination included conventional clinical-laboratory...
Practice of Dapagliflozin Application in Patients with Type 2 Diabetes Mellitus
The article presents the results of using new antihyperglycemic drug — a selective inhibitor of the sodium-glucose cotransporter type 2 — dapagliflozin in patients with type 2 diabetes mellitus. The influence of this dru...
On the Scientific Popularization of Knowledge about Diabetes (Problems and Judgments)
.
Results of Long-Term Follow-Up of Patients with Benign Nodules of Thyroid Gland
The aim of the study was to conduct automated analysis of long-term follow up of patients with benign focal tumors of the thyroid gland. We have studied the results of observation of 7083 patients. It is revealed that 28...