Pathogenetic and clinical correlation of type 2 diabetes mellitus with metabolic syndrome and chronic coronary artery disease
Journal Title: Міжнародний ендокринологічний журнал - Year 2018, Vol 14, Issue 7
Abstract
Background. Increase of morbidity of diabetes mellitus (DM) associated with coronary artery disease (CAD) on the background of metabolic syndrome (MS) is worrisome. It is very important to improve the diagnosis of this associated pathology and also to develop pathogenetic therapy, taking into account the specific stage of disease. The purpose of our work was to study the correlation of compensated and decompensated type 2 DM on the background of MS with chronic CAD. Materials and methods. 231 patients with MS and with or without type 2 DM and chronic CAD were examined. MS was characterized by the II–IIІ degree of obesity in all studied groups. The levels of cortisol, prolactin, free thyroxine, thyroid-stimulating hormone (TSH), lipids were evaluated in all patients, ultrasonography of the heart was performed. Results. Increase of cortisol levels, prolactin in women, TSH, change of lipids as high levels of triglycerides, very low-density lipoprotein cholesterol, at the control value of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and total cholesterol was detected in patients with metabolic syndrome, and also patients with compensated type 2 DM on the background of MS. Increase of interventricular septal thickness and left atrium anteroposterior dimension was observed in patients of this group. Increased levels of cortisol and prolactin as well as the control level of TSH were detected in patients with MS and decompensated type 2 DM as well as with or without chronic CAD. Increase of interventricular septal thickness, left ventricular posterior wall thickness, left atrium anteroposterior dimension was observed in patients of both groups according to results of ultrasonography. High level of total cholesterol, low-density lipoprotein cholesterol, triglycerides, very low-density lipoprotein cholesterol and low level of high-density lipoprotein cholesterol were observed in patients with MS and decompensated type 2 DM associated with chronic CAD compared to patients with MS and type 2 DM without chronic CAD. Conclusions. The pathogenetic and clinical relation of type 2 DM was established in MS and chronic CAD.
Authors and Affiliations
R. Ya. Dutka, N. V. Chmyr
Keywords
Related Articles
- EP ID EP432672
- DOI 10.22141/2224-0721.14.7.2018.148772
- Views 33
- Downloads 0
The Content of Insulin-Like Growth Factor 1 and Essential Trace Elements in the Blood Plasma of Children with Different Forms of Short Stature
The content of insulin-like growth factor 1 and essential trace elements (zinc, selenium, copper, manganese, chromium) was studied in the blood plasma of children with short stature, depending on the etiology of the dise...
Testosterone and Quality of Women’s Life (Literature Review)
Sexual desire disorder is a common clinical problem that may have a very negative impact on a woman’s quality of life. Diagnosis and treatment are challenging, as one must keep in mind the complex web of factors influenc...
Features of pahogocytic activity of monocytes and neutrophils in patients with obesity and ankylosinig spondylitis depending on HLA B27 gene carrier
Background. Ankylosing spondylitis (AS) is a widespread pathology all over the world. The AS prevalence in different countries ranges from 0.2 to 2 %. Usually the disease debuts at the age of 20–40 years, men suffer from...
Legal Work of the Doctor at the Stage of Primary Health Care
The article deals with the main problems of medical care providing in primary health care, as well as the settlement of legal relations arising in the work of the doctor, and the need for systematization of legal acts wh...
Neuroendocrine and Cardiovascular Risk Factors in Adults with Pituitary Growth Hormone Deficiency (Literature Review)
In this article authors discussed the results of literature review, which has been dedicated to study of different complications of growth hormone deficiency in adults, referring to the literature of the last 10–15 years...