Pathogenetic Features of Gastroduodenal Peptic Ulcer Associated with Hypertension and Diabetes Mellitus Type 2
Journal Title: Міжнародний ендокринологічний журнал - Year 2016, Vol 2, Issue 74
Abstract
The development and course of gastroduodenal peptic ulcer are associated with the strains of H.pylori (сagA+ vacA+, сagA+ vacА–, сagA– vacA+, сagA– vacA–) that was found in patients in the presence of comorbidity and in its absence. In the group of patients with gastroduodenal peptic ulcer combined with hypertension and diabetes mellitus type 2, сagA+ vacA+ strains were found in 14 individuals (45.16 %), сagA+ vacA– — in 4 (12.9 %), сagA– vacA+ — in 13 (41.43 %), and in patients with gastroduodenal peptic ulcer — in 4 (13.79 %), 8 (27.59 %) and 16 (55.17 %) persons, respectively. The impact of H.pylori strains is associated with the changes of proteolytic and fibrinolytic activity. Given the comorbidity and the role of strains in the development of underlying disease, there has been revealed a probable reduction in the level of albumin lysis, azocasein lysis and an increase in azocol lysis compared with reduced total fibrinolytic activity, non-enzymatic fibrinolytic enzyme activity and increased enzymatic fibrinolytic activity. The use of baseline anti-Helicobacter pylori therapy and probiotics (Lactobacterium, Bifidobacterium) provides a positive result.
Authors and Affiliations
I. O. Sitsinska
Keywords
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