Pathogenetic justification and clinical significance of using arginine for prevention of critical ischemia of lower extremities and fatal manifestations of multifocal atherosclerosis
Journal Title: Серце і судини - Year 2018, Vol 0, Issue 4
Abstract
The aim — to investigate the results of treatment with L‑arginine of patients with intermittent claudication for prevention of critical stages of limb ischemia. Materials and methods. 86 patients with intermittent claudication were randomly divided into two groups of 43 patients each. Patients of the first group received 8 g of L‑arginine (Tivortin) twice a day, patients of the second group — 40 mg of prostaglandin E1 (PGE1) twice a day. Results and discussion. Administration of L‑arginine contributed to an increase in the distance of painless walk by 230 ± 63 %, the absolute walk distance — by 155 ± 48 % (p < 0.05), the administration of PGE1 — by 209 ± 63 % and 144 ± 28 %, respectively (p < 0.05). Treatment with L‑arginine increased the value of the coefficient of L‑arginine/asymmetric dimethylarginine in plasma and the excretion of nitrates and cGMP in the urine, which indicated the normalization of the biosynthesis of endogenous NO. PGE1 therapy did not significantly affect endothelium‑dependent vasodilation parameters. The coefficient of quality of life, estimated in an analog scale, increased from 3.51 ± 0.18 to 8.3 ± 0.4 in the arginine group and to 7.0 ± 0.5 in the PGE1 group (all p < 0.05). Conclusions. Arginine is a drug of choice to prevention of severe forms of lower limbs ischemia and other manifestations of multifocal atherosclerosis.
Authors and Affiliations
V. G. Mishalov, V. A. Chernyak, O. I. Sopko, D. Ye. Dubenko
Infarction mask of aortoarteritis
Arteritis Takayasu (AT) belongs to the group of systemic vasculitis with a predominant lesion of vessels of large diameter. This disease is characterized by granulomatous inflammation of the aorta and its main branches....
Heart failure with preserved ejection fraction: phantom or real independent syndrome with «own face»?
-
Living activities limitation of population of Ukraine due to chronic venous diseases of lower limbs
The aim — to analyze the level and structure of primary (PD) and accumulated disability (AD) due to chronic venous diseases of the lower extremities (CVDLE) over the past five years in Ukraine. Materials and methods. T...
Preoperative planning of on-pump beating-heart coronary artery bypass grafting based on prediction of intraoperative complications
The aim — to improve the results of coronary artery bypass grafting in patients with ischemic heart disease by determining indications for direct myocardial revascularization on a beatingheart in conditions of parallel...
Assessment of life quality of patients with trophic ulcer of venous genesis
The aim — to assess life quality of patients with trophic ulcers of venous genesis Materials and methods. A survey of 85 patients who are on inpatient treatment for venous trophic ulcers was conducted. According to the C...