Pathological differences between clinically suspected and unsuspected gallbladder carcinoma: A 5- year retrospective study
Journal Title: Pathology Update: Tropical Journal of Pathology and Microbiology - Year 2017, Vol 3, Issue 3
Abstract
Introduction: Gallbladder carcinoma frequently presents as incidental finding in routine cholecystectomy specimens operated for gallstone diseases. The reason behind unrecognition of these tumors pre and intraoperatively and its significance need evaluation. Objective: We have done a 5 years retrospective study from December 2011 to November 2016 in a referral centre to evaluate the pathological features of unsuspected gallbladder carcinoma and to compare these with those of suspected carcinomas. Methods: A total record of 74 cases of gallbladder carcinomas are retrieved from the archives. These are 54 whole gallbladder specimens of simple and extended cholecystectomies and 24 small tissue pieces of gallbladder. Out of 54 whole gallbladder specimens 30 are clinically unsuspected and 24 are suspected carcinomas. Result: Majority of the unsuspected group have diffusely thickened gallbladder wall as their sole gross presentation or no grossly identifiable lesion at all. On the other hand, suspected gallbladder carcinomas have presented mostly as localized wall thickening, thickened wall with invasion of the adjacent structures or large intraluminal mass. Adenocarcinoma was the commonest histological type in suspected and exclusive type in unsuspected group. Most of the unsuspected carcinomas are well differentiated in contrast to the suspected carcinomas which are mostly poorly differentiated followed by almost equal prevalence of moderately differentiated and well differentiated tumors. Half of the unsuspected tumors are limited to gallbladder and no cases of pT4 stage are present. On the contrary, only one fourth of cases of the suspected carcinomas are limited to gallbladder and another one fourth are in pT4 stage. Conclusion: Unsuspected gallbladder carcinoma show different gross presentation and also tend to be better differentiated and in earlier stages than suspected carcinomas.
Authors and Affiliations
Prabir Hazarika, Rasadhar Deka, Manoj K Sharma
Keywords
Related Articles
- EP ID EP264172
- DOI 10.17511/jopm.2017.i3.01
- Views 122
- Downloads 0
A clinicopathological study of salivary gland tumors
Background:To evaluate tumors involving major and minor salivary glands, histopathology is an essential diagnostic method and is the gold standard. This study was carried out to know the incidence of salivary gland tumor...
A study on Vulvovaginal candidiasis among non-pregnant women
Introduction: Candida species are opportunistic pathogens which cause a wide variety of infections in humans ranging from trivial intertriginous infection to fatal candidemia. Vulvo vaginal candidiasis (VVC) is an acute...
A prospective study of the palpable lesions of the breast and the role of FNAC in these lesions with available histopathology methods
Introduction: Benign as well as malignant breast lesions are quite common in Indian population. It is the second most common cancer site after cancer cervix. Fine-needle aspiration cytology (FNAC) is safe, reliable, and...
Pathological differences between clinically suspected and unsuspected gallbladder carcinoma: A 5- year retrospective study
Introduction: Gallbladder carcinoma frequently presents as incidental finding in routine cholecystectomy specimens operated for gallstone diseases. The reason behind unrecognition of these tumors pre and intraoperatively...
Semen analysis in smokers and non-smokers
Background: Semen analysis still remains as a simple, cost effective screening test for evaluation of male in fertility clinic, which provides information on quantitative and qualitative aspects of testicular function. E...