Pathomorphological features of wound process in the experiment
Journal Title: Хірургія України - Year 2018, Vol 0, Issue 2
Abstract
The aim — to study the pathomorphological features of wound process in the experiment under the influence of developed applicational sorbent. Materials and methods. The research was held on 40 adult white rats‑males line Vistar. Purulent wounds were modeled on them. The animals were divided into two groups: main and comparative. In the main group (20 rats), the local treatment of wounds was carried out using up‑date application sorbent, which included aerosil and immobilized ornidazole and serratiopeptidase. The second group consisted of two subgroups. Each subgroup had a total of 10 rats. In group A the treatment was carried out with application sorbent hentaxan and in group B we used 10 % NaCl solution and ointment levomekol. Results and discussion. Fourteens days after, the main group animals showed a completely epithelized wound surface that was covered with multilayer squamous epithelium and under it the fibrous connective tissue had grown, the vessels were formed and apoptosis reaction was negative. In group A the surface of the wound was with fibric purulent layers. The granulation tissue area was narrowed and the quantity of capillary structures were reduced, the cells with apoptosis were accumulated. In the group B the surface of the wound was covered with a small quantity of necrotic detritus of local infiltration. The purulent exudate was formed and spread on granulation tissue. The apoptosis was moderate. Conclusions. The main group indicated first signs of endotheliocyte proliferation with capillary generation and granulation tissue formation and epithelium formation were more than 1.5 times earlier than in comparative group.
Authors and Affiliations
O. O. Bilyayeva, V. V. Kryzhevsky, V. I. Zaritska, I. V. Karol
Keywords
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- EP ID EP359204
- DOI 10.30978/SU2018252
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