Pathophysiological mechanisms of alcoholic myopathy - Lessons from rodent models
Journal Title: Journal of Veterinary and Animal Sciences - Year 2021, Vol 52, Issue 2
Abstract
Skeletal muscle dysfunction is highly prevalent and is one of the earliest pathological tissue changes among people with at-risk alcohol use. Clinical studies to elucidate pathophysiological mechanisms of alcohol-mediated muscle disease are hampered due to ethical considerations, and confounded by nutritional, lifestyle, and comorbid conditions. Rodent models have been developed to study the impact of at-risk alcohol consumption and alcohol-mediated end organ injury, including skeletal muscle dysfunction. This review discusses results from well-established rodent models of alcohol administration and highlights key pathophysiological mechanisms underlying alcoholic myopathy identified in rodent models. Salient pathways include impaired regenerative capacity, altered anabolic/catabolic balance, impaired mitochondrial bioenergetic function, and skeletal muscle morphological and contractile changes.
Authors and Affiliations
Danielle E. Levitt Patricia E. Molina Liz Simon
Keywords
Related Articles
- EP ID EP699160
- DOI 10.51966/jvas.2021.52.2.107-116
- Views 78
- Downloads 0
Oestrus ovis larvae in nasal cavity of sheep: A case report
Oestrosis, caused by the larvae of Oestrus ovis, is an obligatory myiasis of sheep and goats. It is commonly known as sheep nasal bot. The present study reports the infestation of the nasal cavity of sheep by Oestrus ov...
Evaluation of haematological and serum biochemical profile of propofol induced isoflurane anaesthesia in geriatric dogs premedicated with diazepam and butorphanol
Six geriatric dogs of various breeds belonging to either sex presented for various surgical procedures to Teaching Veterinary Clinical Complex, Mannuthy and University Veterinary Hospital, Kokkalai, were selected for th...
Factors affecting gestation length in small sized breeds of dogs
A large variation in the gestation length can be expected when the gestation is calculated from the day of mating to birth. The present study was designed to assess the influence of different factors like litter size, b...
Annual temperature profile of Thrissur: a climate change perspective
Climate change is one of the most serious issues faced by the global community of the present era. Hence, maximum, minimum and average temperatures for the period 1986 to 2016 collected from the Department of Agricultur...
Life cycle and development rate of Hemipyrellia ligurriens (Wiedemann) (Diptera: Calliphoridae) during monsoon season in South India: applications in estimation of postmortem interval
Hemipyrellia ligurriens, considered as one of the forensically important blow fly species, has a wide distribution in many countries including India. To conduct forensic entomological investigations involving deaths of...