Pathophysiology of Complex Regional Pain Syndrome Type I: Update
Journal Title: International Journal of Anesthesiology & Research (IJAR) - Year 2015, Vol 3, Issue 7
Abstract
Background: Complex regional pain syndrome type I (CRPS I), also known as reflex sympathetic dystrophy (RSD), develops as disabling painful disorder following a trauma or surgery to a limb. We provide a review based on the current literature concerning the epidemiology and pathophysiology of CRPS I. Possible pathophysiological mechanisms of CRPS I are inflammation, sympathetic-afferent coupling and cortical changes. Methods: A literature search was conducted using, as electronic bibliographic database, Medline from 1980 until today. Results: CRPS I is a multifactorial disorder with complex aetiology and pathogenesis. Conclusions: The pathophysiology of CRPS I is complex and may change during its course. CRPS I is more than a peripheral disease because peripheral mechanisms such as neurogenic inflammation and sympathetic-afferent coupling inconclusively explain its pathophysiology. CRPS I is a pain disorder involving the somatosensory, the somatomotor and the sympathetic nervous systems. Genetic findings suggest there might be a predisposition to CRPS I and it has been confirmed in multiple studies that psychological factors are not predictors for the development of CRPS I. The complexity and diversity of the mechanisms involved will be liable to the heterogeneity of the clinical presentation and may explain the difficulty of achieving an evidence-based treatment of CRPS I.
Authors and Affiliations
Martino Bussa
Keywords
Related Articles
- EP ID EP202324
- DOI 10.19070/2332-2780-1500035
- Views 132
- Downloads 0
Anti-Xa Assay Correlation to the Efficacy and Safety of Enoxaparin in the Treatment of Pulmonary Embolism
Background: Enoxaparin is one of the LMWH that has been used for long time in the treatment of acute pulmonary embolism. In this study, we will monitor anticoagulant therapy by anti-Xa assay and correlate its level to th...
Serotonin Syndrome Following Methylene Blue Administration for Vasoplegic Syndrome in Heart and Lung Transplantation – A Case Series
Serotonin syndrome is a potentially life threatening adverse drug reaction caused by excessive activation of postsynaptic serotonin receptors in the central nervous system (CNS). It is typically associated with the simul...
Identifying Surgery and Anesthesia - Related Anxiety in Patients Undergoing Colorectal Cancer Surgery
Objective: In patients where colorectal cancer surgery is planned, anxiety is triggered not only by cancer diagnosis, but also potentially by the surgery and anesthesia preoperatively. We aimed to determine preoperative...
What Every Anesthesiologist Must Know About Congenital Heart Disease
What Every Anesthesiologist Must Know About Congenital Heart Disease
Factors Impacting the Likelihood of Death in Patients in Intensive Care Unit
Background and Purpose: Intensive care units are special treatment units with high-tech equipment developed for the treatment and follow up of life-threatening organ failure seen in the course of both chronic and acute i...