Patient with metastatic renal cell carcinoma treated successfully with pazopanib for four years.

Journal Title: OncoReview - Year 2015, Vol 5, Issue 3

Abstract

We present a case of a patient with metastatic renal cell carcinoma who was treated with pazopanib in the first-line treatment. Although nephrectomy was not performed, there was a positive reaction to the therapy with multi targeted tyrosine kinase inhibitor. After 18 months of the palliative treatment, the cancerous kidney was surgically removed and pazopanib was restarted with the effect of further disease remission. The development of hypertension, complete hair discoloration and isolated hyperbilirubinemia occurred, and there was occasionally hypokalaemia in laboratory findings within 48 months of therapy. No serious adverse events were reported.

Authors and Affiliations

Agnieszka Słowik, Joanna Streb, Robert Chrzan, Krzysztof Krzemieniecki

Keywords

Related Articles

Chemotherapy in gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN)

Approximately two-thirds of malignant GEP-NENs are metastatic at discovery. Chemotherapy with platinum and etoposide is a standard therapy for poorly differentiated GEP-NEC. For well-differentiated pancreatic GEP-NEN ass...

Cisplatin-induced cardiotoxicity – two case reports

Cisplatin has been used for over 40 years in various cancer chemotherapies. Toxicity induced by cisplatin-based therapeutic regimens include gastrointestinal toxicity, myelotoxicity, neurotoxicity, ototoxicity and nephro...

Long-term response with everolimus for metastatic renal cell carcinoma refractory to sunitinib-sorafenib sequence

We presented a 39-year-old male who developed progressive cancer disease 4 years after nephrectomy due to clear cell carcinoma. He was diagnosed with locally reccurence and metastases to the liver, spleen and abdominal m...

Późny nawrót przewlekłej białaczki szpikowej po alogenicznym przeszczepieniu komórek macierzystych - opis przypadku

Przewlekła białaczka szpikowa obecnie w większości przypadków jest chorobą dobrze poddającą leczeniu inhibitorami kinazy tyrozynowej. Nadal jednak jedyną procedurą leczniczą dającą możliwość wyleczenia jest aloprzeszczep...

Rehabilitation of patients with cancer of the respiratory system

Many patients with lung cancer have concomitant chronic obstructive pulmonary disease and heart diseases. The planned anticancer therapy should be individualized in relationship of patient’s cardiac and pulmonary conditi...

Download PDF file
  • EP ID EP78720
  • DOI 10.5604/20828691.1171780
  • Views 209
  • Downloads 0

How To Cite

Agnieszka Słowik, Joanna Streb, Robert Chrzan, Krzysztof Krzemieniecki (2015). Patient with metastatic renal cell carcinoma treated successfully with pazopanib for four years.. OncoReview, 5(3), 109-116. https://europub.co.uk/articles/-A-78720