Pattern of Adverse Drug Reactions to Conventional Anti-epileptic Drugs Monotherapy in Nepalese Children
Journal Title: Nepal Journal of Neuroscience - Year 2009, Vol 6, Issue 1
Abstract
Adverse drug reactions (ADRs) are common with anti-epileptie drug (AED) therapy. Knowledge about ADRs helps the clinician in planning the treatment course and facilitates early detection of ADRs and intervention. Present study was done to find out the pattern of ADRs to conventional AEDs monotherapy in Nepalese children. This is a prospective study done at a medical college, teaching hospital, pediatric out patient department, epilepsy clinic. New patients on monotherapy of one of the four conventional major AEDs were followed up, monitored and recorded for adverse effects. Total number of patients were 74 of whom ADR was observed in 32 patients (43.24%). Maximum ADRs rate was seen with phenobarbitone (83.33%). CNS side effect was most commonly seen (43.75%). Most ADRs were of mild severity (60%) and recovery occurred spontaneously. AED is one of the three commonest drug classes associated with ADRs in children. Present study is of small size but it Has increased ADRs awareness and encouraged it’s early detection. Further larger studies are needed.
Authors and Affiliations
Kashyap N Shakya, FCPS
Keywords
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