Pattern of lipid alterations in subclinical hypothyroidism: response to Levothyroxine replacement
Journal Title: International Journal of Medical Research and Review - Year 2017, Vol 5, Issue 9
Abstract
Objectives: (1)To assess the association of subclinical hypothyroidism (SCH) and lipid profile (2) To quantify the effect of thyroxine treatment on lipid profile.Methods:In a non-randomized matched design, 320 patients who were detected to have SCH and 180 euthyroid controls, matched for age and BMI (body-mass index), werestudied for lipid parameters.Subjects with SCH were further subdivided on the basis of their thyroid functional status: SCH with TSH≤10.0 mIU/L (SCH-1) and SCH with TSH>10 mIU/L (SCH-2). Subjects in SCH-2 group were started on thyroxine replacement and were followed up after 3 months with a repeat lipid profile. Results:Mean total cholesterol(TC) and low-density lipoprotein(LDL) levels were higher and mean high-density lipoprotein (HDL) significantly lower in SCH (SCH-1 and SCH-2) compared to euthyroid controls, but there was no statistically significant difference in the mean triglyceride(TG)levels. Subjects in SCH-2 group had significantly higher mean LDL and lower mean HDL compared to SCH-1 group.There was a significant reduction in mean TC andLDL and increase in HDLafter treatment with thyroxine, while there was no significant difference among the mean TG levels.Conclusion:Subclinical hypothyroidism is associated with TSH dependent rise in TC and LDL and fall in HDL compared to controls. Achieving euthyroid status with thyroxine has a favourable effect on lipid profile.
Authors and Affiliations
Nazir Ahmad Pala, Mohd Ashraf, Badrinath Bhoughal
Keywords
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- EP ID EP274684
- DOI 10.17511/ijmrr. 2017.i09.06
- Views 143
- Downloads 0
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