Pattern of metabolic abnormalities in patients with hyperprolactinemia - Response to treatment with Cabergoline
Journal Title: Journal of Medical Sciences - Year 2015, Vol 18, Issue 1
Abstract
BACKGROUND: Hyperprolactinemia has been associated with changes in body composition and metabolic abnormalities. Normalization of prolactin with dopamine agonists has been found to reverse these metabolic abnormalities. MATERIAL & METHODS: Prospective case-controlled study. Twenty consecutive patients, 18 women and 2 men with hyperprolactinemia and 20 age, gender (18 women and 2 men) and body mass index matched controls were included in the study. Anthropometric data and metabolic variables were studied in both cases and controls at baseline and again at 3 and 6 months after cabergoline treatment in patients with hyperprolactinemia. RESULTS: Patients with hyperprolactinemia had significantly increased level of fasting plasma glucose, LDL-cholesterol, triglycerides, leptin and lower levels of estradiol as compared to age, gender, and weight-matched healthy controls. Anthropometric data revealed a significant decrease of body weight (p< 0.001), body mass index (p<0.001), waist circumference (p=0.02), waist-hip ratio (p=0.02) and total body fat (p=0.003) at 6 months of cabergoline treatment. Similarly, there was a significant decline in abnormal metabolic parameters like plasma glucose (p<0.001), total cholesterol (p=0.004), LDL cholesterol (p<0.001), triglycerides (p<0.001) and leptin (p=0.013) after 6 months of cabergoline treatment. Serum estradiol levels improved significantly with marginal improvement in insulin sensitivity (as measured by HOMA IR) at 6 months. CONCLUSIONS: Patients with hyperprolactinemia had high body weight, body mass index, leptin, lower estradiol concentration, adverse glucose and lipid profile. Normalization of prolactin with cabergoline corrected all the metabolic abnormalities.
Authors and Affiliations
Nazir Ahmad Pala, Bashir Ahmad Laway
Keywords
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