Pattern of Thyroid Functional Derangements in Patients with Metabolic Syndrome
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 20, Issue 9
Abstract
Aim: To study the pattern of thyroid functional derangements in patients with metabolic syndrome. Methods: The current study was designed as a cross sectional descriptive study of 130 patients with metabolic syndrome. Results: The mean age was 57.5, with 88 [67.69%] females. According to HOMA-IR estimation; 129 (99.2%) of the studied patients were found to have insulin resistance. Subclinical hypothyroidism was diagnosed in 34 (26.15%). There was no age or sex difference between patients with and without subclinical hypothyroidism however a significant higher prevalence of dyslipidemia (high triglyceride, 25[73.53%] vs. 33[34.38%,], p=0.001) and (low HDL-C, 34[100%] VS. 81[84.38%], P=0.01) in patients with compared to without subclinical hypothyroidism respectively. Also, the mean ± SD waist circumference (138.6 cm ± 1.4 vs 118.9 ± 9.9, p=0.001) and waist/hip ratio (1.24 ± 0.08 vs. 1.098 ± 0.09, p= 0.001) were significantly higher in patients with compared to without subclinical hypothyroidism respectively. There was no statistically significant difference between the two groups regarding HOMA-IR. In addition, there was no significant correlation between HOMA-IR and either free thyroxine (FT4) or thyroid stimulating hormone (TSH). However, TSH was significantly positively correlated with triglycerides; R= 0.2, P=0.02 and negatively correlated with HDL-C; R=-.02, P=0.01. There was significant strong positive correlation between TSH and obesity parameters (waist circumference; R=0.6, P=0.001 and waist/hip ratio; R=0.5, P=0.001), while a significant negative correlation was found between FT4 and fasting insulin; R= -0.2, 0.04, waist circumference; R= -0.2, P=0.01 and waist hip ratio; R= -0.3, P=0.002. The area under the ROC (95% CI) was 0.93 (0.88-0.97), P=0.001 for the waist circumference as a predictor of subclinical hypothyroidism with a sensitivity of 97% and specificity of 81%, while that of waist / hip ratio was 0.86 (0.79-0.91), p=0.001, with a sensitivity of 91% and specificity of 77%. Conclusion: Subclinical hypothyroidism is prevalent among patients with metabolic syndrome. TSH is significantly associated with metabolic syndrome parameters particularly dyslipidemia and obesity indicators.
Authors and Affiliations
A. Ali, M. Abdu
Keywords
Related Articles
- EP ID EP311483
- DOI 10.9734/BJMMR/2017/32311
- Views 52
- Downloads 0
Scalp Metastasis from Thyroid Carcinoma 12 Years Post-thyroidectomy: Clinical and Ethical Lessons
Aim: We describe a rare presentation of thyroid carcinoma, to highlight thyroid carcinoma in the differential diagnosis of skin lesions; and emphasize the importance of efficient record keeping in patient management. Pre...
Adherence to Lifestyle Modifications among Adult Hypertensive Nigerians with Essential Hypertension in a Primary Care Clinic of a Tertiary Hospital in Resource-poor Environment of Eastern Nigeria
Background: Lifestyle modifications (LSMs) are indispensable in blood pressure control among hypertensive patients. However, the extent to which patients lifestyles (LS) coincide with clinical prescriptions has become an...
Nasopharyngeal Carcinoma: An Awareness and Screening Initiative in Boston’s Chinatown
Aims: Our objective is to describe our institutional experience with nasopharyngeal carcinoma (NPC), and the initiation of a community education and screening program. Study Design: Retrospective case series; academic m...
Awareness of the Oral Cancer Risk Factors in People from Nothern-Eastern Region of Poland
Background: The aim of the study presented in this paper is to investigate patient knowledge about the existence of oral cancer and the awareness of the impact of smoking on the development of this malignancy. Methods: P...
Barriers, Facilitators, Strategies, and Predictors for Reporting Adverse Drug Reactions in three General Hospitals in Jeddah, 2013
Background: Adverse drug reactions (ADRs) are the main cause of significant morbidity and mortality worldwide. The identification of barriers, facilitators, strategies, and predictors for reporting ADRs helps in the prev...